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首页> 外文期刊>RSC Advances >Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging
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Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

机译：原子转移自由基聚合（ATRP）制备两亲性荧光聚赖氨酸纳米粒子及其在细胞成像中的应用

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Due to the good biocompatibility, epsilon-polylysine (Ply) has been extensively investigated for various biomedical applications. In this study, a fluorescent monomer (named Flu-MA) was firstly synthesized through acylation reaction of fluorescein by methacryloyl chloride, and the initiator of epsilon-polylysine bromide (named Ply-Br) was prepared by the introduction of a bromine atom into Ply by the acylation reaction of Ply with alpha-bromoisobutyryl bromide. Subsequently, a novel amphiphilic fluorescent polymer (Flu-Ply) was successfully fabricated by ATRP via incorporation of Flu-MA monomer into Ply chains for the first time. The structure and properties of the obtained Flu-Ply fluorescent polymer were investigated in detail by H-1 NMR, TEM, UV-vis, FL and FTIR, and the results confirmed the successful incorporation of Flu-MA into Ply by ATRP. As a result of Flu-MA and Ply respectively endowing the as-prepared Flu-Ply polymer with fluorescence and water dispersibility, it tended to self-assemble into fluorescent organic nanoparticles (FONs) with excellent biocompatibility. More importantly, the good fluorescence, uniform spherical morphology, excellent biocompatibility and water dispersibility of Flu-Ply FONs exhibited an attractive prospect for bioimaging applications.
机译：由于良好的生物相容性，ε-聚赖氨酸（Ply）已被广泛研究用于各种生物医学应用。在这项研究中，首先通过荧光素与甲基丙烯酰氯的酰化反应合成了荧光单体（称为Flu-MA），然后通过将溴原子引入Ply中制备了ε-聚赖氨酸溴化物的引发剂（称为Ply-Br）。通过Ply与α-溴异丁酰溴的酰化反应。随后，通过ATRP成功地将Flu-MA单体首次引入Ply链中，成功制备了新型两亲性荧光聚合物（Flu-Ply）。通过H-1 NMR，TEM，UV-vis，FL和FTIR对所得Flu-Ply荧光聚合物的结构和性能进行了详细研究，结果证实了ATRP成功将Flu-MA掺入P​​ly中。由于Flu-MA和Ply分别使制得的Flu-Ply聚合物具有荧光和水分散性，因此它倾向于自组装成具有出色生物相容性的荧光有机纳米颗粒（FON）。更重要的是，Flu-Ply FON的良好荧光，均匀的球形形态，出色的生物相容性和水分散性为生物成像应用展现了诱人的前景。

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