• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Self-assembly of glycinin nanoparticles for delivery of phenolic compounds from Phyllanthus urinaria
【24h】

Self-assembly of glycinin nanoparticles for delivery of phenolic compounds from Phyllanthus urinaria

机译：大豆球蛋白甘氨酸纳米粒的自组装，用于从余甘子中释放酚类化合物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this work was to fabricate and evaluate glycinin nanoparticles for delivery of phenolic compounds from Phyllanthus urinaria. The nanoparticles were prepared using self-assembly method, and three variables, including pH (X-1), glycinin concentration (X-2) and glycinin to phenolic compounds mass ratio (X-3) for the achievement of high encapsulation efficiency of phenolic compounds, were optimized using response surface methodology. The statistical analyses show that the independent variables (X1, X2) and the quadratic terms (X1 2, X2 2 and X3 2) have significant effect on the encapsulation efficiency. The optimized conditions are X-1 of 4.4, X-2 of 3.2 mg mL(-1), and X-3 of 6.2 : 1. Under these conditions, the experimental value is 51.42% (n = 3), which is well matched with the predicted value. Scanning electron microscopy (SEM) micrograph and dynamic light scattering (DLS) analyses show that the nanoparticles have an approximately spherical morphology with a smooth surface, and the mean particle size was about 100 nm with a narrow size distribution of 0.318. The release of phenolic compounds shows a faster release at pH 7.4 but a lower release at pH 1.2, and the release mechanism at pH 1.2 and 7.4 is Fickian diffusion and anomalous transport, respectively.
机译：这项工作的目的是制造和评估大豆球蛋白甘氨酸纳米颗粒，用于从毛竹楠中释放酚类化合物。采用自组装法制备了纳米颗粒，并实现了pH（X-1），大豆球蛋白浓度（X-2）和大豆球蛋白与酚类化合物质量比（X-3）这三个变量，以实现酚类的高包封率。使用响应面方法对化合物进行了优化。统计分析表明，自变量（X1，X2）和二次项（X1 2，X2 2和X3 2）对封装效率有显着影响。优化的条件是X-1为4.4，X-2为3.2 mg mL（-1）和X-3为6.2：1。在这些条件下，实验值为51.42％（n = 3），这很好。与预测值匹配。扫描电子显微镜（SEM）显微照片和动态光散射（DLS）分析表明，纳米颗粒具有近似球形的形态，表面光滑，平均粒径约为100 nm，粒径分布窄，为0.318。酚类化合物的释放在pH 7.4时显示较快的释放，而在pH 1.2时则较低，并且在pH 1.2和7.4时的释放机理分别为Fickian扩散和异常运输。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号