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Preparation and antibacterial activity of chitosan derivative membrane complexation with iodine

机译：壳聚糖衍生物与碘络合的制备及抑菌活性

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Hydroxypropyl chitosan biguanide hydrochloride (HPCGH) was synthesized through the method of "amino protection-graft reaction-deprotection", the HPCGH membrane (HPCGH-PVP-M) was then prepared from a mixture of gelatin and polyvinylpyrrolidone (PVP), following that, the iodine membrane (HPCGH-PVP-I-2-M) was obtained via the adsorption of iodine in iodine alcohol solution. The properties of HPCGH-PVP-I-2-M were characterized by Fourier-transform infrared (FT-IR), H-1-NMR, X-ray diffraction (XRD) as well as thermogravimetric analysis (DTG) studies. The investigation results suggest that HPCGH-PVP-I-2-M has a better amorphous structure and a better thermal stability compared to that of HPCGH-PVP-M. Investigations were carried out on the iodine content demonstrating that HPCGH-PVP-M has superior properties for the adsorption of iodine. The iodine release studies in this work showed that HPCGH-PVP-I-2-M emitted iodine slowly and kept the iodine for a long time, and that HPCGH-PVP-I-2-M had the property of sustained-release iodine, furthermore, the higher the temperature and the higher the iodine content, the faster the release of iodine was. It was also found that the antibacterial activity of HPCGH-PVP-I-2-M against E. coli and S. aureus was better than that of HPCGH-PVP-M and that the inhibition zone diameters increased with an increase in the amount of iodine. When the content of iodine was 16.02% and the temperature was 37 degrees C, the inhibition zone diameters of HPCGH-PVP-I-2-M against E. coli and S. aureus were approximately 28 +/- 1 mm and 30 +/- 1 mm, respectively, hence the significant antibacterial activity.
机译：通过“氨基保护-接枝反应-去保护”的方法合成羟丙基壳聚糖双胍盐酸盐（HPCGH），然后由明胶和聚乙烯吡咯烷酮（PVP）的混合物制备HPCGH膜（HPCGH-PVP-M），然后，通过碘在碘醇溶液中的吸附获得碘膜（HPCGH-PVP-I-2-M）。通过傅立叶变换红外（FT-IR），H-1-NMR，X射线衍射（XRD）以及热重分析（DTG）研究来表征HPCGH-PVP-I-2-M的性质。研究结果表明，与HPCGH-PVP-M相比，HPCGH-PVP-I-2-M具有更好的非晶结构和更好的热稳定性。对碘含量进行了研究，表明HPCGH-PVP-M具有优异的碘吸附性能。这项工作中的碘释放研究表明，HPCGH-PVP-I-2-M缓慢释放碘并长时间保持碘，并且HPCGH-PVP-I-2-M具有缓释碘的特性，此外，温度越高，碘含量越高，碘的释放越快。还发现HPCGH-PVP-I-2-M对大肠杆菌和金黄色葡萄球菌的抗菌活性要好于HPCGH-PVP-M，且抑制区的直径随的增加而增加。碘。当碘含量为16.02％且温度为37℃时，HPCGH-PVP-I-2-M对大肠杆菌和金黄色葡萄球菌的抑制带直径约为28 +/- 1 mm和30 + / -1 mm，因此具有显着的抗菌活性。

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