Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells.

Roussi S; Winter A; Gosse F; Werner D; Zhang X; Marchioni E; Geoffroy P; Miesch M; Raul F

首页> 外文期刊>Cell death and differentiation >Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells.

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Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells.

机译：不同的凋亡机制参与了7β-羟基谷甾醇和7β-羟基胆固醇在人结肠癌细胞中的抗增殖作用。

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Plant sterols are found in fruits and vegetables. Their cholesterol-lowering effect is well documented. Our study aimed at comparing antiproliferative effects of 7beta-hydroxysitosterol (7beta-OHsito) versus 7beta-hydroxycholesterol (7beta-OHchol) on the human colon cancer cell line Caco-2. When cells were exposed for 32 h to 60 microM 7beta-OHsito or to 30 microM 7beta-OHchol, both compounds caused 50% growth inhibition. Cells treated with 7beta-OHsito showed enhanced caspase-9 and -3 activities followed by DNA fragmentation. In contrast, 7beta-OHchol did not activate caspase-3 and activation of caspase-9 and DNA fragmentation were delayed. The treatment of cells with the caspase inhibitor Z-VAD.fmk retarded the 7beta-OHsito-induced apoptotic process but not that triggered by 7beta-OHchol. Our data suggest that the two compounds in spite of their structural similarities target different cellular pathways, which lead to cell death.

机译：植物固醇存在于水果和蔬菜中。降低胆固醇的作用已得到充分证明。我们的研究旨在比较7beta-羟基谷甾醇（7beta-OHsito）和7beta-羟基胆固醇（7beta-OHchol）对人结肠癌细胞系Caco-2的抗增殖作用。当细胞暴露于60 microM 7beta-OHsito或30 microM 7beta-OHchol 32小时后，两种化合物均导致50％的生长抑制。用7beta-OHsito处理的细胞显示出增强的caspase-9和-3活性，随后发生DNA断裂。相比之下，7beta-OHchol不会激活caspase-3，并且caspase-9的激活和DNA片段被延迟。用半胱天冬酶抑制剂Z-VAD.fmk处理细胞可延缓7beta-OHsito诱导的凋亡过程，但不能阻止7beta-OHchol触发的凋亡过程。我们的数据表明，尽管这两种化合物的结构相似，但它们靶向不同的细胞途径，从而导致细胞死亡。

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《Cell death and differentiation》 |2005年第2期|共8页
作者
Roussi S; Winter A; Gosse F; Werner D; Zhang X; Marchioni E; Geoffroy P; Miesch M; Raul F;
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正文语种 eng
中图分类基础医学;
关键词
Apoptosis; Cell Proliferation; Hydroxycholesterols; Sitosterols; 脱噬作用; 羟基胆甾醇类; 谷甾醇;

机译：Apoptosis;Cell Proliferation;Hydroxycholesterols;Sitosterols;脱噬作用;羟基胆甾醇类;谷甾醇;

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1. Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. [J] . Roussi S, Winter A, Gosse F, Cell death and differentiation . 2005,第2期

机译：不同的凋亡机制参与了7β-羟基谷甾醇和7β-羟基胆固醇在人结肠癌细胞中的抗增殖作用。
2. Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms [J] . Abaza Mohamed-Salah I., Bahman Abdul-Majeed, Al-Attiyah Rajaa J. International journal of molecular medicine . 2014,第2期

机译：丙戊酸，一种抗癫痫药和一种组蛋白脱乙酰基酶抑制剂，与蛋白酶体抑制剂联合使用，可在人大肠癌细胞中发挥抗增殖，促凋亡和化学增敏作用：潜在的分子机制
3. Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms [J] . AbazaMohamed-Salah I., BahmanAbdul-Majeed, Al-AttiyahRaja#39, International journal of molecular medicine . 2014,第2期

机译：与蛋白酶体抑制剂组合的丙戊酸，抗癫痫药物和组蛋白脱乙酰酶抑制剂在人结肠直肠癌细胞中施加抗增殖，促细胞凋亡和化学溶解作用：潜在的分子机制
4. Antiproliferative Effect of Fucoxanthin and Its Metabolites on Human Prostate Cancer Cells. [C] . International Symposium on the Efficient Application and Preservation of Marine Biological Resourecs; 20041029-1102; Qingdao(CN) . 2004

机译：岩藻黄质及其代谢产物对人前列腺癌细胞的抗增殖作用。
5. The multiple antiproliferative effects and molecular mechanisms of 3,3'-diindolylmethane (DIM) in human breast cancer cells. [D] . Hong, Chibo. 2001

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6. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action [O] . Marilena Kampa, Vassilia-Ismini Alexaki, George Notas, 2004

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7. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action [O] . 2003

机译：选择性酚酸对T47D人乳腺癌细胞的抗增殖和凋亡作用：潜在的作用机制

Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells.

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