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首页> 外文期刊>Russian journal of genetics >The 1xC3 panel of recombinant inbred mouse strains. Presence or absence of pathologic neurologic traits of one of parental strains
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The 1xC3 panel of recombinant inbred mouse strains. Presence or absence of pathologic neurologic traits of one of parental strains

机译：1xC3重组自交系小鼠品系。父母亲菌株之一的病理神经系统特征是否存在

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摘要

Mice from the earlier developed recombinant inbred strains (RIS), which were derived by crossing 101/HY mice (carrying the mut-1 allele determining increased susceptibility to the mutagenic action of alkylating compounds) with C3H/Sn mice (lacking this trait), were tested for the presence of two neurological pathologies, audiogenic epilepsy and splitting of pyramidal cell layer of the CA3 hippocampal field (specific only to 101/HY mice). It was demonstrated that segregation of RIS relative to these traits was independent from the presence or absence of the mut-1 allele. These findings suggested the appearance of mut-1-independent mutations in the 101/HY mice, which resulted in the development of neurological pathologies. The appearance of such mutations can be the consequence of the genetic repair defects, earlier observed in the mice with this genotype.
机译：来自较早开发的重组自交系（RIS）的小鼠，它们是通过与C3H / Sn小鼠（无此特性）杂交101 / HY小鼠（携带mut-1等位基因，确定其对烷基化化合物诱变作用的敏感性增加）而获得的，测试了两种神经病理学的存在：听觉性癫痫和海马CA3区锥体细胞分裂（仅对101 / HY小鼠具有特异性）。已证明相对于这些性状的RIS分离与mut-1等位基因的存在与否无关。这些发现表明在101 / HY小鼠中出现了不依赖mut-1的突变，这导致了神经病理学的发展。这种突变的出现可能是基因修复缺陷的结果，这种缺陷在具有该基因型的小鼠中较早地观察到。

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