...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Occupational and environmental medicine >Age at exposure to ionising radiation and cancer mortality among Hanford workers: follow up through 1994.
【24h】

Age at exposure to ionising radiation and cancer mortality among Hanford workers: follow up through 1994.

机译：汉福德工人在暴露于电离辐射中的年龄和癌症死亡率：随访至1994年。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Studies of workers at the plutonium production factory in Hanford, WA have led to conflicting conclusions about the role of age at exposure as a modifier of associations between ionising radiation and cancer. AIMS: To evaluate the influence of age at exposure on radiation risk estimates in an updated follow up of Hanford workers. METHODS: A cohort of 26 389 workers hired between 1944 and 1978 was followed through 1994 to ascertain vital status and causes of death. External radiation dose estimates were derived from personal dosimeters. Poisson regression was used to estimate associations between mortality and cumulative external radiation dose at all ages, and in specific age ranges. RESULTS: A total of 8153 deaths were identified, 2265 of which included cancer as an underlying or contributory cause. Estimates of the excess relative risk per Sievert (ERR/Sv) for cumulative radiation doses at all ages combined were negative for all cause and leukaemia and positive for all cancer and lung cancer. Cumulative doses accrued at ages below 35, 35-44, and 45-54 showed little association with mortality. For cumulative dose accrued at ages 55 and above (10 year lag), the estimated ERR/Sv for all cancers was 3.24 (90% CI: 0.80 to 6.17), primarily due to an association with lung cancer (ERR/Sv: 9.05, 90% CI: 2.96 to 17.92). CONCLUSIONS: Associations between radiation and cancer mortality in this cohort are primarily a function of doses at older ages and deaths from lung cancer. The association of older age radiation exposures and cancer mortality is similar to observations from several other occupational studies.
机译：背景：在华盛顿州汉福德市production生产工厂进行的工人研究得出的结论相互矛盾，即暴露年龄是电离辐射与癌症之间联系的调节剂。目的：在汉福德工人的最新随访中，评估暴露年龄对辐射风险估计的影响。方法：在1944年至1978年之间雇用了26 389名工人，直到1994年为止，以确定生命状态和死亡原因。外部辐射剂量估计值来自个人剂量计。 Poisson回归用于估计所有年龄以及特定年龄范围内的死亡率与累积外部辐射剂量之间的关联。结果：共鉴定出8153例死亡，其中2265例包括癌症为潜在或共同原因。在所有年龄段的累积辐射剂量下，每西弗特（Sievert）的相对相对危险度（ERR / Sv）的估计值对所有原因和白血病均为阴性，而对所有癌症和肺癌均为阳性。低于35岁，35-44岁和45-54岁的累积剂量与死亡率几乎没有关系。对于55岁及以上（滞后10年）的累积剂量，所有癌症的ERR / Sv估计为3.24（90％CI：0.80至6.17），主要是由于与肺癌相关（ERR / Sv：9.05， 90％CI：2.96至17.92）。结论：在该队列中，放射线与癌症死亡率之间的关系主要是年龄较大的剂量和肺癌死亡的函数。老年辐射暴露与癌症死亡率之间的关系与其他几项职业研究的观察结果相似。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号