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首页> 外文期刊>Occupational and environmental medicine >The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone.
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The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone.

机译：石棉沉着症对肺癌风险的影响超出单独的石棉剂量相关作用。

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AIMS: To determine if the presence of asbestosis is a prerequisite for lung cancer in subjects with known exposure to blue asbestos (crocidolite). METHODS: Former workers and residents of Wittenoom with known amounts of asbestos exposure (duration, intensity, and time since first exposure), current chest x ray and smoking information, participating in a cancer prevention programme (n = 1988) were studied. The first plain chest radiograph taken at the time of recruitment into the cancer prevention programme was examined for radiographic evidence of asbestosis according to the UICC (ILO) classification. Cox proportional hazards modelling was used to relate asbestosis, asbestos exposure, and lung cancer. RESULTS: Between 1990 and 2002 there were 58 cases of lung cancer. Thirty six per cent of cases had radiographic evidence of asbestosis compared to 12% of study participants. Smoking status was the strongest predictor of lung cancer, with current smokers (OR = 26.5, 95% CI 3.5 to 198) having the greatest risk. Radiographic asbestosis (OR = 1.94, 95% CI 1.09 to 3.46) and asbestos exposure (OR = 1.21 per f/ml-year, 95% CI 1.02 to 1.42) were significantly associated with an increased risk of lung cancer. There was an increased risk of lung cancer with increasing exposure in those without asbestosis. CONCLUSION: In this cohort of former workers and residents of Wittenoom, asbestosis is not a mandatory precursor for asbestos related lung cancer. These findings support the hypothesis that it is the asbestos fibres per se that cause lung cancer, which can develop with or without the presence of asbestosis.
机译：目的：确定在已知接触蓝色石棉（青石棉）的受试者中是否存在石棉沉滞症是肺癌的先决条件。方法：对参加维特努姆的前工人和居民进行了已知的石棉暴露量（持续时间，强度和第一次暴露后的时间），当前的胸部X射线和吸烟信息，并参加了一项癌症预防计划（n = 1988）。根据UICC（ILO）分类，检查了招募入癌症预防计划时拍摄的第一张胸部平片，以获取石棉沉陷的放射影像学证据。使用Cox比例风险建模将石棉沉着，石棉暴露和肺癌联系起来。结果：1990年至2002年之间，有58例肺癌。百分之三十六的病例有放射线照相法显示有石棉沉滞，而研究参与者为百分之十二。吸烟状况是肺癌的最强预测指标，目前的吸烟者（OR = 26.5，95％CI 3.5至198）风险最高。放射线石棉石化（OR = 1.94，95％CI 1.09至3.46）和石棉暴露（OR = 1.21每f / ml-年，95％CI 1.02至1.42）与肺癌风险增加显着相关。没有石棉沉滞症的人随着暴露的增加而患肺癌的风险增加。结论：在这个来自维滕努姆的前工人和居民的队列中，石棉沉着症不是石棉相关性肺癌的强制性前兆。这些发现支持以下假说：石棉纤维本身会导致肺癌，无论有无石棉病都可能发展为肺癌。

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