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首页> 外文期刊>Occupational and environmental medicine >Incidence of respiratory sensitisation and allergy to enzymes among employees in an enzyme producing plant and the relation to exposure and host factors.
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Incidence of respiratory sensitisation and allergy to enzymes among employees in an enzyme producing plant and the relation to exposure and host factors.

机译：产酶工厂员工的呼吸道过敏和对酶过敏的发生率，以及与暴露和宿主因素的关系。

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OBJECTIVES: Belonging to the group of high molecular weight respiratory sensitisers, microbial enzymes have been reported as a well known cause of occupational allergy, typically manifesting itself as rhinitis and/or asthma. High exposure to such high molecular weight sensitisers, and possibly also peak exposures, implies a higher risk than low exposure, but the exact relation between exposure, sensitisation and clinical allergy remains to be clarified. The authors sought to estimate the risk of respiratory enzyme allergy in an enzyme producing plant and to assess the relation between exposure indices and allergy. METHODS: Retrospective follow-up study based upon data gathered from health surveillance since 1970. 1207 employees from production and laboratories were included. The level of enzyme exposure in the relevant departments was estimated retrospectively into five exposure levels based on 10-fold increments/decrements of the threshold limit value and other exposure information. The risk was estimated in an exponential regression survival model fitted with constant intensity for subperiods of time using maximum likelihood estimation. RESULTS: During the first three years of a person's employment, the enzyme sensitisation and allergy incidence rates were 0.13 and 0.03 per person-year at risk, respectively. In the fitted models, exposure class did not correlate with the outcome variables. The risk of sensitisation decreased along the three decades, whereas the risk of allergy remained unchanged. The risk of sensitisation and allergy was doubled among smokers. Pre-employment atopy was only associated with sensitisation risk. CONCLUSION: Sensitisation to enzymes decreased during the study period, possibly reflecting improvements in the working environment. A similar decrease could not be demonstrated for allergy to enzymes. Neither of the two outcomes correlated with exposure estimates, possibly because of the low precision of the estimates.
机译：目的：属于高分子量呼吸道敏化剂的一种，据报道微生物酶是职业过敏的众所周知原因，通常表现为鼻炎和/或哮喘。与低暴露量相比，高暴露量的此类高分子量敏化剂可能会暴露出更高的风险，但是暴露量，致敏性与临床过敏之间的确切关系仍有待阐明。作者试图评估酶生产植物中呼吸道酶过敏的风险，并评估暴露指数与过敏之间的关系。方法：基于1970年以来从健康监测收集的数据进行回顾性随访研究。其中包括来自生产和实验室的1207名员工。根据阈值限值的10倍增/减量和其他暴露信息，将相关部门中的酶暴露水平回顾性评估为5个暴露水平。风险是在指数回归生存模型中进行估计的，该模型使用最大似然估计在一段时间内以恒定强度拟合时间。结果：在一个人就业的前三年中，处于危险状态的人的酶敏化和过敏发生率分别是每人年0.13和0.03。在拟合模型中，暴露类别与结果变量不相关。在过去的三十年中，致敏的风险降低，而过敏的风险保持不变。吸烟者致敏和过敏的风险增加了一倍。就业前特应性仅与致敏风险有关。结论：在研究期间，对酶的敏感性降低了，这可能反映了工作环境的改善。对于酶的过敏也不能证明有类似的减少。这两个结果均与暴露估计值不相关，这可能是因为估计值的准确性较低。

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