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Exposure assessment should be integrated in studies on the prevention and management of occupational asthma.

机译:暴露评估应纳入职业性哮喘预防和管理研究中。

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摘要

Evidence-based medicine (EBM) approaches have recently been applied to occupational asthma. The EBM document by Newman Taylor et al for occupational asthma evaluates, among other issues, the existence of exposure-response relations for sensitisation and asthma. The cited references indeed provide evidence that exposure-response curves exist for certain high molecular weight allergens. The risk for allergen-specific sensitisation and asthma increases steeply with increasing allergen exposure, especially in atopics. More sensitised individuals express respiratory symptoms at higher exposure than at low exposure. The time to development of allergy is shorter at higher exposures than at lower exposure.
机译:循证医学(EBM)方法最近已应用于职业性哮喘。纽曼·泰勒(Newman Taylor)等人针对职业性哮喘的EBM文件评估了致敏和哮喘的暴露-反应关系的存在以及其他问题。引用的参考文献确实提供了证据,表明某些高分子量过敏原存在暴露-反应曲线。过敏原特异性致敏和哮喘的风险随着过敏原暴露的增加而急剧增加,特别是在过敏性疾病中。较高的暴露水平比低暴露水平更易引起呼吸道症状。较高的暴露水平比较低的暴露水平更容易引起过敏。

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