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首页> 外文期刊>Occupational and environmental medicine >Vitamin B12 and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate.
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Vitamin B12 and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate.

机译：长期接触铬酸盐的工人体内维生素B12和叶酸缺乏以及血浆总同型半胱氨酸水平升高。

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OBJECTIVES: Chronic occupational exposure to chromium can result in a broad range of adverse effects including multiple organ damage, genotoxicity and carcinogenesis. However, the metabolic consequences of chromium exposure have not been fully investigated. This study was designed to examine vitamin B12, folate and homocysteine metabolic changes in workers chronically exposed to chromate. The potential association between metabolic alteration and renal impairment induced by chromate exposure was also assessed. METHODS: The level of chromium exposure was evaluated by measuring chromium concentrations in red blood cells (RBC-Cr) and urine (U-Cr). Renal impairment was assessed with serum cystatin C (Cys-C) and urinary beta2-microglobulin (beta2M). Serum vitamin B(12), folate and plasma total homocysteine (tHcy) were measured and correlations analysed. RESULTS: Significant increases in RBC-Cr, U-Cr, serum Cys-C, plasma tHcy and urinary beta2M concentrations were observed in workers chronically exposed to chromate compared to controls. In the exposed workers, serum vitamin B12 and folate levels were decreased and significantly inversely correlated with RBC-Cr concentrations, and increased plasma tHcy concentrations were mirrored by decreased serum vitamin B12 and folate levels. Elevated plasma tHcy concentrations were positively related to serum Cys-C concentrations. CONCLUSIONS: Hyperhomocysteinemia in chronically exposed workers was primarily induced by vitamin B12 and folate deficiency. This metabolic change might be associated with renal dysfunction in chromate processing workers after long term exposure.
机译：目的：长期职业性接触铬可导致广泛的不良反应，包括多器官损伤，遗传毒性和致癌作用。但是，铬暴露的代谢后果尚未得到充分研究。这项研究旨在检查长期接触铬酸盐的工人的维生素B12，叶酸和高半胱氨酸代谢变化。还评估了代谢改变与铬酸盐暴露引起的肾功能损害之间的潜在关联。方法：通过测量红细胞（RBC-Cr）和尿液（U-Cr）中铬的浓度来评估铬的暴露水平。用血清半胱氨酸蛋白酶抑制剂C（Cys-C）和尿中的β2-微球蛋白（beta2M）评估肾功能损害。测量血清维生素B（12），叶酸和血浆总同型半胱氨酸（tHcy）并分析相关性。结果：与对照组相比，长期接触铬酸盐的工人观察到RBC-Cr，U-Cr，血清Cys-C，血浆tHcy和尿中beta2M浓度显着增加。在暴露的工人中，血清维生素B12和叶酸水平降低，并且与RBC-Cr浓度呈显着负相关，而血浆tHcy浓度升高反映了血清维生素B12和叶酸水平的降低。血浆tHcy升高与血清Cys-C浓度呈正相关。结论：长期暴露的工人高同型半胱氨酸血症主要是由维生素B12和叶酸缺乏引起的。长期暴露后，这种代谢变化可能与铬酸盐加工工人的肾功能不全有关。

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