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首页> 外文期刊>Occupational and environmental medicine >Occupational exposure to chlorinated solvents and risks of glioma and meningioma in adults
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Occupational exposure to chlorinated solvents and risks of glioma and meningioma in adults

机译：成人接触氯化溶剂和成人脑胶质瘤和脑膜瘤的风险

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Objectives: Chlorinated solvents are classified as probable or possible carcinogens. It is unknown whether exposure to these agents increases the risk of malignant or benign brain tumours. Our objective was to evaluate associations of brain tumour risk with occupational exposure to six chlorinated solvents (ie, dichloromethane, chloroform, carbon tetrachloride, 1,1,1-trichloroethane, trichloroethylene and perchloroethylene). Methods: 489 glioma cases, 197 meningioma cases and 799 controls were enrolled in a hospital-based case-control study conducted at three USA hospitals in Arizona, Massachusetts and Pennsylvania. Information about occupational history was obtained through a detailed inperson interview that included job-specific modules of questions such that the interview was tailored to each individual's particular work history. An industrial hygienist assessed potential solvent exposure based on this information and an exhaustive review of the relevant industrial hygiene literature. Unconditional logistic regression models were used to calculate OR and 95% CI for each solvent for everever, duration, cumulative, average weekly and highest exposure. Results: Overall, we found no consistent evidence of an increased risk of glioma or meningioma related to occupational exposure to the six chlorinated solvents evaluated. There was some suggestion of an association between carbon tetrachloride and glioma in analyses restricted to exposed subjects, with average weekly exposure above the median associated with increased risk compared with below the median exposure (OR = 7.1, 95% CI 1.1 to 45.2). Conclusions: We found no consistent evidence for increased brain tumour risk related to chlorinated solvents.
机译：目标：氯化溶剂被归类为可能或可能的致癌物。暴露于这些药物是否会增加恶性或良性脑瘤的风险还不得而知。我们的目标是评估脑肿瘤风险与职业性接触六种氯化溶剂（即二氯甲烷，氯仿，四氯化碳，1,1,1-三氯乙烷，三氯乙烯和全氯乙烯）的关联。方法：在亚利桑那州，马萨诸塞州和宾夕法尼亚州的三家美国医院进行的一项基于医院的病例对照研究中，纳入了489例神经胶质瘤病例，197例脑膜瘤病例和799例对照。有关职业历史的信息是通过详细的面试获得的，其中包括针对特定岗位的问题模块，从而使面试适合每个人的特定工作经历。一名工业卫生学家根据此信息和对相关工业卫生文献的详尽审查，评估了潜在的溶剂接触量。使用无条件逻辑回归模型计算每种溶剂的有无/无，持续时间，累积，平均每周和最高暴露量的OR和95％CI。结果：总的来说，我们没有一致的证据表明与职业性接触所评估的六种氯化溶剂有关的神经胶质瘤或脑膜瘤风险增加。在仅限于接触受试者的分析中，有人暗示四氯化碳和神经胶质瘤之间存在关联，平均每周接触高于中位数会增加风险，而低于接触中位数（OR = 7.1，95％CI 1.1至45.2）。结论：我们没有一致的证据表明与氯化溶剂有关的脑肿瘤风险增加。

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