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Does uranium induce circulatory diseases? First results from a French cohort of uranium workers

机译：铀会引起循环系统疾病吗？法国一群铀矿工人的初步成果

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Objectives: Increased risk of circulatory system diseases (CSDs) was observed in nuclear workers handling uranium and plutonium in Russia and the UK. This work examines the CSD mortality after chronic intake of uranium among 2897 workers (79 892 person-years) at a uranium processing plant (1960-2006) in France. Methods: Cumulative exposure to different uranium compounds, classified by their isotopic composition and solubility type, was quantified on the basis of a plant-specific job-exposure matrix and individual job histories. HRs and associated 95% CI for CSD (n=111) and specific CSD categories were estimated using Cox regression models, stratified on sex and birth cohort and adjusted for potential confounders. The effect of smoking was analysed among 260 smokers (42 CSD deaths). Results: Compared to unexposed workers, CSD mortality was increased among workers exposed to slowly soluble reprocessed uranium (RPU) (HR=2.13, 95% CI=0.96 to 4.70) and natural uranium (HR=1.73, 95% CI=1.11 to 2.69). The risk increased with cumulative exposure and exposure duration. In the subgroup of smokers, the risk estimates were higher but with larger CIs: HR=1.91 (95% CI=0.92 to 3.98) for natural uranium and HR=4.78 (95% CI=1.38 to 16.50) for RPU. Conclusions: The authors observed that exposure to slowly soluble uranium, namely RPU, may increase the risk of CSD mortality. However, these results are preliminary since the study is lacking statistical power and many other biological and lifestyle-related factors may cause CSD. More detailed investigations are necessary to confirm these findings and analyse in depth the effects of internal radiation exposure on the circulatory system.
机译：目的：在俄罗斯和英国，处理铀和p的核工作人员发现循环系统疾病（CSD）的风险增加。这项工作研究了法国一家铀加工厂（1960-2006年）的2897名工人（79 892人年）中长期摄入铀后CSD的死亡率。方法：根据不同的同位素组成和溶解度类型对不同铀化合物的累积暴露量进行了量化，并基于特定于工厂的工作暴露矩阵和个人工作经历进行了量化。使用Cox回归模型估算了CSD（n = 111）和特定CSD类别的HR和相关的95％CI，并按性别和出生队列进行了分层，并针对潜在的混杂因素进行了调整。分析了260名吸烟者（42名CSD死亡）中吸烟的影响。结果：与未暴露的工人相比，暴露于缓慢溶解的再加工铀（HR = 2.13，95％CI = 0.96至4.70）和天然铀（HR = 1.73，95％CI = 1.11至2.69）的工人的CSD死亡率增加）。风险随着累积暴露和暴露持续时间而增加。在吸烟者亚组中，风险估计较高，但CI较大：天然铀HR = 1.91（95％CI = 0.92至3.98），RPU HR = 4.78（95％CI = 1.38至16.50）。结论：作者观察到，暴露于缓慢溶解的铀即RPU可能会增加CSD死亡的风险。但是，这些结果是初步的，因为该研究缺乏统计能力，许多其他与生物学和生活方式相关的因素也可能导致CSD。为了确认这些发现并深入分析内部辐射暴露对循环系统的影响，有必要进行更详细的研究。

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