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首页> 外文期刊>Occupational and environmental medicine >Relation between colour vision loss and occupational styrene exposure level.
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Relation between colour vision loss and occupational styrene exposure level.

机译：色觉丧失与职业苯乙烯接触水平之间的关系。

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AIMS: To investigate the relation between colour vision loss and the exposure level of styrene. Exposure level included the current exposure concentration, past cumulative exposure, and the maximum exposure level in the past. METHODS: Colour vision was examined by the Lanthony desaturated panel D-15 test for 76 subjects exposed to styrene in a fibreglass reinforced plastics boat plant (as an exposed group) and 102 non-exposed subjects (as a control group). The current exposure level was expressed by the concentration of atmospheric styrene and end shift urinary mandelic acid (MA) and phenylglyoxylic acid (PGA) levels. The individual cumulative exposure index (CEI) was calculated, based on the exposure frequency and urinary MA concentrations measured for the past eight years. RESULTS: The Colour Confusion Index (CCI) of the exposed group showed a significant difference from the age matched controls. However, only a slight significant relation was found between CCI and the concentration of urinary MA plus PGA. In this study, the exposed group was further divided into two subgroups (as sub-MA+PGA groups) by the median of urinary MA plus PGA of each subject. The dividing line between the subgroups was 0.24 g/g creatinine, which was equivalent to an atmospheric concentration of styrene of about 10 ppm. The CCI values of both the sub-MA+PGA groups were significantly higher than that of the control group. The relation between CCI value and the maximum exposure concentration in the past eight years was examined. It was found that the CCI values of the group with the maximum exposure concentration of styrene over 50 ppm were significantly higher than that of the other groups. CONCLUSIONS: Exposure to styrene would impair colour vision even if the exposure concentration was lower than 10 ppm. Furthermore, if the maximum concentration of styrene exposure transiently exceeded 50 ppm in the past, the styrene related damage might remain. Thus, the safe limit of exposure to styrene and the relation between exposure to styrene and the degree of damage to ocular structure, retina, optic nerve, and brain need to be re-examined.
机译：目的：研究色觉丧失与苯乙烯暴露水平之间的关系。暴露水平包括当前的暴露浓度，过去的累积暴露量以及过去的最大暴露量。方法：通过Lanthony脱饱和面板D-15测试，对玻璃纤维增​​强塑料船厂中的76名暴露于苯乙烯的受试者（作为暴露组）和102名未暴露的受试者（作为对照组）进行了色觉检查。当前的暴露水平由大气中苯乙烯的浓度以及端位移尿扁桃酸（MA）和苯乙醛酸（PGA）的浓度表示。根据过去8年的暴露频率和尿中MA浓度，计算出个体累积暴露指数（CEI）。结果：暴露组的颜色混淆指数（CCI）与年龄匹配的对照组相比有显着差异。但是，在CCI与尿液MA和PGA的浓度之间只有很小的显着关系。在这项研究中，根据每个受试者的尿液MA + PGA的中位数，将暴露组进一步分为两个亚组（作为MA + PGA亚组）。亚组之间的分界线为0.24 g / g肌酸酐，相当于大气中约10 ppm的苯乙烯浓度。两个MA + PGA组的CCI值均显着高于对照组。研究了过去八年中CCI值与最大暴露浓度之间的关系。发现苯乙烯的最大暴露浓度超过50ppm的组的CCI值显着高于其他组。结论：即使暴露浓度低于10 ppm，接触苯乙烯也会损害色觉。此外，如果过去苯乙烯暴露的最大浓度瞬时超过50 ppm，则可能会保留与苯乙烯有关的损害。因此，需要重新检查暴露于苯乙烯的安全极限以及暴露于苯乙烯与对眼结构，视网膜，视神经和大脑的损害程度之间的关系。

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