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Biological monitoring of kidney function among workers occupationally exposed to trichloroethylene.

机译：生物接触三氯乙烯的工人肾脏功能的生物监测。

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AIMS: To investigate the nephrotoxic potential of trichloroethylene in a currently exposed population using sensitive urinary markers of kidney toxicity. METHODS: Renal dysfunction was monitored in a cross-sectional study of 70 workers currently exposed to trichloroethylene. An age and sex matched control population of 54 individuals was drawn from hospital and administrative staff. RESULTS: The mean exposure to trichloroethylene, estimated from urinary trichloroacetic acid concentrations, was 32 ppm (range 0.5-252 ppm) with an average duration of exposure of 4.1 years (range 1-20 years). Significant differences between the exposed and control populations were found for nephrotoxicity markers N-acetylglucosaminidase (NAG) and albumin, and for the mode of action marker, formic acid. However, neither NAG nor albumin showed a significant correlation with either the magnitude or duration of exposure to trichloroethylene. There was a significant correlation between urinary formic acid and trichloroacetic acid concentrations. Within the exposed population there were dose dependent increases in urinary methylmalonic acid concentrations and urinary glutathione S-transferase alpha activity. Although still within the control range, these changes were clearly dose dependent and consistent with one of the proposed mechanisms of trichloroethylene induced kidney toxicity. CONCLUSION: Although there was no evidence of kidney toxicity within the population studied, the results suggest that kidney damage could occur at exposure concentrations higher (>250 ppm) than those encountered in this study.
机译：目的：使用敏感的肾脏毒性尿液标记物，调查三氯乙烯在当前暴露人群中的肾毒性潜力。方法：在一项横断面研究中监测了肾功能不全，该研究目前对70名暴露于三氯乙烯的工人进行了研究。从医院和行政管理人员中提取了年龄和性别相匹配的对照人群54人。结果：根据尿中三氯乙酸的浓度估算，三氯乙烯的平均暴露量为32 ppm（范围为0.5-252 ppm），平均暴露时间为4.1年（范围为1-20年）。在暴露和对照人群之间发现了肾毒性标记物N-乙酰氨基葡萄糖苷酶（NAG）和白蛋白以及作用方式标记物甲酸的显着差异。但是，NAG和白蛋白均未显示与三氯乙烯接触的量或持续时间有显着相关性。尿甲酸和三氯乙酸浓度之间存在显着相关性。在暴露人群中，尿甲基丙二酸浓度和尿中谷胱甘肽S-转移酶α活性呈剂量依赖性增加。尽管仍在控制范围内，但这些变化显然是剂量依赖性的，并且与三氯乙烯诱导的肾脏毒性的拟议机制之一一致。结论：尽管没有证据表明所研究的人群具有肾脏毒性，但结果表明，与本研究相比，暴露于更高浓度（> 250 ppm）的肾脏可能会发生肾脏损害。

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