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首页> 外文期刊>Occupational and environmental medicine >Persisting risk of nickel related lung cancer and nasal cancer among Clydach refiners.
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Persisting risk of nickel related lung cancer and nasal cancer among Clydach refiners.

机译：Clydach精炼厂中镍相关的肺癌和鼻癌的持续存在风险。

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摘要

OBJECTIVE: To evaluate the risk of lung cancer and nasal cancer among workers employed at the Clydach nickel refinery, South Wales since 1930 by combining data from the two most recently published papers on this cohort. METHODS: Observed and expected numbers of cancer deaths were extracted for workers who had a minimum of five years service and were employed for the first time between 1902 and 1992. Standardised mortality ratios (SMR) were calculated for subgroups according to year of employment, time since first employment, and process work. RESULTS: A persisting excess of respiratory cancer was found for workers employed in the period 1930-92, with a lung cancer SMR of 133 (95% CI 103 to 172) and a SMR for nasal cancer of 870 (95% CI 105 to 3141). The lung cancer excess was most clearly seen 20 years or more after first employment and seemed to be confined to process workers. There was no indication of a further reduction in risk since 1930. CONCLUSION: The extreme nickel related cancer hazard at the refinery before 1920 was greatly reduced during subsequent years. Some of the carcinogenic exposures seem to have remained after 1930, producing an elevated risk of nasal cancer and a 30% excess of lung cancer in the workforce. There was evidence of a persisting risk among process workers first employed since 1953.
机译：目的：通过结合最近两次发表的有关该队列研究的数据，来评估自1930年以来在南威尔士克莱德（Clydach）镍精炼厂工作的工人患肺癌和鼻癌的风险。方法：从1902年到1992年之间首次工作至少五年的工人中，提取观察到的和预期的癌症死亡人数。按工作年限，时间计算亚组的标准死亡率（SMR）。自从第一次就业以来，就开始工作。结果：发现在1930-92年期间工作的工人持续存在呼吸道癌，肺癌的SMR为133（95％CI 103至172），鼻腔的SMR为870（95％CI 105至3141）。 ）。首次工作20年或更长时间后，最明显地观察到肺癌过量，并且似乎仅限于加工工人。自1930年以来，没有迹象表明风险会进一步降低。结论：1920年以前，炼油厂极度镍相关的癌症风险在随后的几年中已大大降低。在1930年之后，某些致癌物质似乎仍然存在，从而增加了罹患鼻癌的风险，并增加了30％的肺癌患者。有证据表明自1953年以来首次雇用的流程工人中存在持续存在的风险。

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