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首页> 外文期刊>Occupational and environmental medicine >A historical mortality study among bus drivers and bus maintenance workers exposed to urban air pollutants in the city of Genoa, Italy.
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A historical mortality study among bus drivers and bus maintenance workers exposed to urban air pollutants in the city of Genoa, Italy.

机译：对意大利热那亚市暴露于城市空气污染物中的公交车司机和公交车维修工人的历史死亡率研究。

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OBJECTIVE: A historical mortality cohort study was conducted in Genoa, Italy among public transport workers ever employed between 1949 and 1980, to estimate overall and cause-specific mortality from January 1970 to December 2005 and to examine associations between exposure to urban air pollutants and overall and cause-specific mortality. METHODS: Causes of death for 9267 males (6510 bus drivers, 2073 maintenance workers and 601 white collar workers) were coded according to ICD-9. Standardised mortality ratios (SMRs) and 95% CIs were computed by applying Italian and regional male death rates to person-years of observation for the entire cohort and following stratification by longest held job title and length of and time since first employment using the Poisson regression model. RESULTS: There were 2916 deaths and 230,009 person-years of observation; 17 subjects were lost to follow-up. SMRs for all causes, diseases of the circulatory, respiratory, digestive and genitourinary systems, and for accidents were lower than expected. SMRs (95% CI) were increased for lung cancer (1.16, 1.05 to 1.28), non-Hodgkin's lymphoma (1.23, 0.85 to 1.78), Hodgkin's lymphoma (2.14, 1.19 to 3.87) and diabetes mellitus (1.16, 1.05 to 1.28). The SMR for leukaemia was 0.77 (0.51 to 1.16). Hodgkin's lymphoma mortality was significantly increased among bus drivers (1.62, 1.37 to 5.04). Lung cancer risk was significantly increased among all workers after 30 years' employment and among maintenance workers. CONCLUSIONS: The study failed to show any increased risk for leukaemias. The increased mortality from Hodgkin's lymphoma and lung cancer may be associated with long-term exposure to urban air pollution.
机译：目的：在意大利热那亚进行了一项历史性的队列研究，研究对象是1949年至1980年期间曾在公共交通部门工作的工人，以估算1970年1月至2005年12月的总体死亡率和特定原因死亡率，并研究城市空气污染物暴露与总体死亡率之间的关联和特定原因的死亡率。方法：根据ICD-9对9267名男性（6510名公共汽车司机，2073名维修工人和601名白领工人）的死亡原因进行了编码。标准化死亡率（SMR）和95％置信区间的计算方法是，将意大利和区域性男性死亡率应用于整个队列的人年观察值，然后使用泊松回归按持有时间最长的职务和首次就职时间和时间进行分层模型。结果：有2916例死亡和230,009人年的观察。 17名受试者失去随访。所有原因，循环系统，呼吸系统，消化系统和泌尿生殖系统疾病以及事故的SMR均低于预期。肺癌（1.16，1.05至1.28），非霍奇金淋巴瘤（1.23，0.85至1.78），霍奇金淋巴瘤（2.14，1.19至3.87）和糖尿病（1.16，1.05至1.28）的SMRs（95％CI）增加。白血病的SMR为0.77（0.51至1.16）。公交车司机的霍奇金淋巴瘤死亡率显着增加（1.62、1.37至5.04）。工作30年后的所有工人和维修工人的肺癌风险显着增加。结论：该研究未能显示出任何增加的白血病风险。霍奇金淋巴瘤和肺癌导致的死亡率增加可能与长期暴露于城市空气污染有关。

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