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首页> 外文期刊>Occupational and environmental medicine >Systemic inflammation, heart rate variability and air pollution in a cohort of senior adults.
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Systemic inflammation, heart rate variability and air pollution in a cohort of senior adults.

机译：一群成年人中的系统性炎症，心率变异性和空气污染。

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OBJECTIVES: Short-term elevation of ambient particulate air pollution has been associated with autonomic dysfunction and increased systemic inflammation, but the interconnections between these pathways are not well understood. We examined the association between inflammation and autonomic dysfunction and effect modification of inflammation on the association between air pollution and heart rate variability (HRV) in elderly subjects. METHODS: 25 elderly subjects in Steubenville, Ohio, were followed up to 24 times with repeated 30-min ECG Holter monitoring (545 observations). C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), soluble inter-cellular adhesion molecule 1 (sICAM-1), and white blood cell and platelet counts were measured in peripheral blood samples collected in the first month of the study. Increased systemic inflammation was defined for subjects within the upper 20% of the distribution for each marker. A central ambient monitoring station provided daily fine particle (PM(2.5)) and sulphate (SO(4)(2-)) data. Linear mixed models were used to identify associations between inflammatory markers and HRV and to assess effect modification of the association between air pollution and HRV due to inflammatory status. RESULTS: A 5.8 mg/l elevation in CRP was associated with decreases of between -8% and -33% for time and frequency domain HRV outcomes. A 5.1 microg/m(3) increase in SO(4)(2-) on the day before the health assessment was associated with a decrease of -6.7% in the SD of normal RR intervals (SDNN) (95% CI -11.8% to -1.3%) in subjects with elevated CRP, but not in subjects with lower CRP (p value interaction=0.04), with similar findings for PM(2.5). CONCLUSIONS: Increased systemic inflammation is associated with autonomic dysfunction in the elderly. Air pollution effects on reduced SDNN are stronger in subjects with elevated systemic inflammation.
机译：目的：短期内升高环境微粒空气污染与植物神经功能紊乱和全身性炎症增加有关，但这些途径之间的相互联系尚不清楚。我们检查了炎症和自主神经功能障碍之间的关联，以及炎症修饰对老年人中空气污染和心率变异性（HRV）之间关联的影响。方法：对俄亥俄州Steubenville的25位老年受试者进行了24次随访，并重复了30分钟的ECG动态心电图监测（545观察）。在第一个月收集的外周血样本中测量C反应蛋白（CRP），纤维蛋白原，白介素6（IL-6），可溶性细胞间粘附分子1（sICAM-1）以及白细胞和血小板计数研究。对于每种标记，在分布的上部20％以内的受试者定义为全身炎症增加。中央环境监测站提供了每日细颗粒（PM（2.5））和硫酸盐（SO（4）（2-））数据。线性混合模型用于确定炎症标志物与HRV之间的关联，并评估由于炎症状态而导致的空气污染与HRV之间的关联的影响修正。结果：CRP升高5.8 mg / l时域和频域HRV结果降低了-8％至-33％。健康评估前一天SO（4）（2-）增加5.1 microg / m（3），与正常RR间隔（SDNN）的SD降低-6.7％（95％CI -11.8）相关CRP升高的受试者中的百分比（-1.3％），但CRP较低的受试者（p值相互作用= 0.04）则没有，PM（2.5）的发现相似。结论：系统性炎症增加与老年人的自主神经功能障碍有关。在全身性炎症升高的受试者中，空气污染对降低SDNN的影响更强。

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