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首页> 外文期刊>Occupational and environmental medicine >Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register.
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Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register.

机译：胸膜外恶性间皮瘤和石棉暴露的发生率，来自意大利国家登记簿。

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OBJECTIVES: The epidemiology of extrapleural malignant mesothelioma is rarely discussed and the risk of misdiagnosis and the very low incidence complicate the picture. This study presents data on extrapleural malignant mesothelioma from the Italian National Mesothelioma Register (ReNaM). METHODS: ReNaM works on a regional basis, searching for cases and interviewing subjects to investigate asbestos exposure. Classification and code criteria for certainty of diagnosis and exposure modalities are set by national guidelines. Between 1993 and 2004, 681 cases were collected. Incidence measures and exposure data refer to the ReNaM database. Age-standardised rates were estimated by the direct method using the Italian resident population in 2001. Correlations between the incidence of pleural and non-pleural malignant mesothelioma for the 103 Italian provinces were analysed. RESULTS: Standardised incidence rates (Italy, 2004, per million inhabitants) were 2.1 and 1.2 cases for the peritoneal site (in men and women, respectively), 0.2 cases for the tunica vaginalis testis, and 0.1 in the pericardial site, varying widely in different parts of the country. Mean age at diagnosis for all extrapleural malignant mesothelioma cases was 64.4 years and the men/women ratio was 1.57:1. Median latency was over 40 years for all extrapleural sites combined. The correlation between pleural and peritoneal mesothelioma was 0.71 (Pearson's r coefficient, p<0.001). Modalities of exposure to asbestos fibres were investigated for 392 cases. CONCLUSIONS: The rarity of the disease, the low specificity of diagnosis and difficulties in identifying the modalities of asbestos exposure call for caution in discussing aetiological factors other than asbestos.
机译：目的：很少讨论胸膜外恶性间皮瘤的流行病学，误诊的风险和极低的发病率使情况复杂化。这项研究提供了来自意大利国家间皮瘤登记簿（ReNaM）的胸膜外恶性间皮瘤数据。方法：ReNaM在区域范围内工作，搜索病例并采访受试者以调查石棉暴露。诊断和暴露方式确定性的分类和编码标准由国家指南设定。在1993年至2004年之间，共收集了681个案例。发病率指标和暴露数据参考ReNaM数据库。通过直接方法使用意大利常住人口于2001年估算年龄标准化率。分析了意大利103个省的胸膜和非胸膜恶性间皮瘤发病率之间的相关性。结果：腹膜部位的标准化发病率（意大利，2004年，每百万居民）分别为2.1例和1.2例（分别为男性和女性），阴道睾丸0.2例和心包部位0​​.1例，差异很大。国家的不同地区。所有胸膜外恶性间皮瘤病例的诊断平均年龄为64.4岁，男女比例为1.57：1。所有胸膜外部位加在一起的中位潜伏期超过40年。胸膜间皮瘤与腹膜间皮瘤之间的相关系数为0.71（Pearson's r系数，p <0.001）。调查了392例石棉纤维的暴露方式。结论：该疾病的罕见性，诊断的特异性低以及难以确定石棉暴露的方式，因此在讨论除石棉以外的其他病因时需要谨慎。

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