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首页> 外文期刊>Occupational and environmental medicine >Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study.
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Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study.

机译：职业接触溶剂和淋巴瘤亚型的风险：Epilymph病例对照研究的结果。

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BACKGROUND: Several studies have suggested an association between occupational exposure to solvents and lymphoma risk. However, findings are inconsistent and the role of specific chemicals is not known. Objective To investigate the role of occupational exposure to organic solvents in the aetiology of B-cell non-Hodgkin's lymphoma (B-NHL) and its major subtypes, as well as Hodgkin's lymphoma and T-cell lymphoma. METHODS: 2348 lymphoma cases and 2462 controls participated in a case-control study in six European countries. A subset of cases were reviewed by a panel of pathologists to ensure diagnostic consistency. Exposure to solvents was assessed by industrial hygienists and occupational experts based on a detailed occupational questionnaire. RESULTS: Risk of follicular lymphoma significantly increased with three independent metrics of exposure to benzene, toluene and xylene (BTX) (combined p=4 x 10(-7)) and to styrene (p=1 x 10(-5)), and chronic lymphocytic leukaemia (CLL) risk increased with exposure to solvents overall (p=4 x 10(-6)), BTX (p=5 x 10(-5)), gasoline (p=8 x 10(-5)) and other solvents (p=2 x 10(-6)). Risk of B-NHL for ever exposure to solvents was not elevated (OR=1.1, 95% CI 1.0 to 1.3), and that for CLL and follicular lymphoma was 1.3 (95% CI 1.1 to 1.6) and 1.3 (95% CI 1.0 to 1.7), respectively. Exposure to benzene accounted, at least partially, for the association observed with CLL risk. Hodgkin's lymphoma and T-cell lymphoma did not show an association with solvent exposure. CONCLUSION: This analysis of a large European dataset confirms a role of occupational exposure to solvents in the aetiology of B-NHL, and particularly, CLL. It is suggested that benzene is most likely to be implicated, but we cannot exclude the possibility of a role for other solvents in relation to other lymphoma subtypes, such as follicular lymphoma. No association with risk of T-cell lymphoma and Hodgkin's lymphoma was shown.
机译：背景：多项研究表明，职业性接触溶剂与淋巴瘤风险之间存在关联。但是，发现并不一致，并且具体化学品的作用尚不清楚。目的探讨职业性接触有机溶剂在B细胞非霍奇金淋巴瘤（B-NHL）及其主要亚型以及霍奇金淋巴瘤和T细胞淋巴瘤的病因中的作用。方法：2348名淋巴瘤病例和2462名对照参加了六个欧洲国家的病例对照研究。一组病理学家对一部分病例进行了检查，以确保诊断的一致性。工业卫生学家和职业专家根据详细的职业调查表对溶剂的接触进行了评估。结果：滤泡性淋巴瘤的风险随着苯，甲苯和二甲苯（BTX）（组合p = 4 x 10（-7））和苯乙烯（p = 1 x 10（-5））的三个独立指标而显着增加，和慢性淋巴细胞性白血病（CLL）的风险随着整体暴露于溶剂（p = 4 x 10（-6）），BTX（p = 5 x 10（-5）），汽油（p = 8 x 10（-5））而增加）和其他溶剂（p = 2 x 10（-6））。从未接触过B-NHL的风险没有升高（OR = 1.1，95％CI 1.0至1.3），而CLL和滤泡性淋巴瘤的风险分别为1.3（95％CI 1.1至1.6）和1.3（95％CI 1.0）至1.7）。苯暴露至少部分原因与CLL风险相关。霍奇金淋巴瘤和T细胞淋巴瘤与溶剂暴露无关。结论：对大型欧洲数据集的分析证实了职业性接触溶剂在B-NHL（尤其是CLL）的病因中的作用。暗示最有可能牵涉苯，但我们不能排除与其他淋巴瘤亚型（例如滤泡性淋巴瘤）有关的其他溶剂起作用的可能性。没有显示与T细胞淋巴瘤和霍奇金淋巴瘤的风险相关。

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