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首页> 外文期刊>Occupational and environmental medicine >Particulate matter and out-of-hospital coronary deaths in eight Italian cities.
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Particulate matter and out-of-hospital coronary deaths in eight Italian cities.

机译：意大利八个城市的颗粒物和院外冠状动脉死亡。

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OBJECTIVES: We evaluated the association between PM(10) concentration and out-of-hospital coronary deaths in eight Italian cities during 1997-2004. METHODS: 16 989 subjects aged >35 years who died out-of-hospital from coronary causes were studied and hospital admissions in the previous 2 years identified. We studied the effect of the mean of current and previous day PM(10) values (lag 0-1). A city-specific case-crossover analysis was applied using a time-stratified approach considering as confounders weather, holidays, influenza epidemics, and summer decrease in population. The pooled percentage increase (95% CI) in mortality per 10 microg/m(3) increase in PM(10) was estimated. RESULTS: A statistically significant increase in out-of-hospital coronary deaths was related to a 10 microg/m(3) increase in PM(10): 1.46% (95% CI 0.50 to 2.43). Although no statistically significant effect modification by age was found, the effect was stronger among subjects aged >65 years (1.60%, 0.59 to 2.63), particularly those aged 65-74 (3.01%, 0.74 to 5.34). People in the lowest socio-economic category (3.34%, 1.28 to 5.45) had a stronger effect than those in the highest category. No clear effect modification was seen for gender, season or any specific comorbidity. An indication of negative effect modification was seen for previous admission for cardiac dysrhythmias. Subjects without hospital admissions in the previous 2 years were slightly more affected by PM(10) effects (1.91%, 0.28 to 3.47) than those with at least one previous hospital admission (1.44%, 0.09 to 2.82). CONCLUSIONS: Our results show that short term exposure to PM(10) is associated with coronary mortality especially among the elderly and socio-economically disadvantaged. No clear effect modification by previous hospitalisations was detected except for cardiac dysrhythmias, possibly due to protective treatment.
机译：目的：我们评估了1997-2004年意大利八个城市中PM（10）浓度与院外冠心病死亡之间的关系。方法：研究了16989名年龄大于35岁的因冠心病原因在院外死亡的受试者，并确定了前2年的住院治疗。我们研究了当前和前一天的PM（10）平均值（滞后0-1）的影响。考虑到混杂因素天气，假日，流行性感冒和夏季人口减少，使用了时间分层方法进行了特定城市的病例交叉分析。估计每增加10 microg / m（3）PM（10），死亡率增加的合并百分比（95％CI）。结果：院外冠状动脉死亡的统计学显着增加与PM（10）的10 microg / m（3）增加有关：1.46％（95％CI为0.50至2.43）。尽管未发现年龄之间的统计学显着性改变，但在65岁以上的受试者（1.60％，0.59至2.63）中，尤其在65-74岁的受试者（3.01％，0.74至5.34）中，该效应更强。社会经济地位最低的人群（3.34％，1.28至5.45）的影响要强于社会地位最高的人群。性别，季节或任何特定合并症均未见明显效果改变。先前出现心脏节律不齐的迹象表明有不良反应。前两年未入院的受试者受PM（10）效应的影响（1.91％，0.28至3.47）比之前至少一次入院的受试者（1.44％，0.09至2.82）受到的影响更大。结论：我们的结果表明，短期暴露于PM（10）与冠心病死亡率相关，尤其是在老年人和社会经济弱势人群中。除心律失常外，未发现因先前住院而引起的明显疗效改变，这可能是由于保护性治疗所致。

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