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Particulate air pollution and preeclampsia: A source-based analysis

机译：空气污染与先兆子痫：基于源的分析

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Objectives: To investigate the association between preeclampsia and maternal exposure to ambient particulate matter (PM) with aerodynamic diameter less than 10 μm (PM10) and 2.5 μm (PM2.5) mass and sources. Methods: Our analysis was based on a hospital cohort of pregnant women (N=3182) residing in Barcelona, Spain, during 2003-2005. Positive matrix factorisation source apportionment (PMF2) was used to identify sources of PM10 and PM2.5 samples obtained by an urban background monitor, resulting in detection of eight sources. We further combined traffic-related sources (brake dust, vehicle exhaust and secondary nitrate/organics) to generate an indicator of combined traffic sources. Logistic regression models were developed to estimate the association between preeclampsia and exposure to each PM source and mass separately during the entire pregnancy and trimester one, adjusted for relevant covariates. Results: For the exposure during the entire pregnancy, we found a 44% (95% CI 7% to 94%) and a 80% (95% CI 4% to 211%) increase in the risk of preeclampsia associated with one IQR increase in exposure to PM10 brake dust and combined traffic-related sources, respectively. These findings remained consistent after an alternative source apportionment method (Multilinear Engine (ME2)) was used. The results for PM2.5 mass and sources and also exposure during trimester one were inconclusive. Conclusions: Risk of preeclampsia was associated with exposure to PM10 brake dust and combined traffic-related sources.
机译：目的：研究子痫前期与孕妇暴露于空气动力学直径小于10μm（PM10）和2.5μm（PM2.5）的质量和来源的环境颗粒物（PM）之间的关系。方法：我们的分析是基于2003-2005年居住在西班牙巴塞罗那的孕妇队列（N = 3182）。使用正矩阵分解源分配（PMF2）来识别由城市背景监测仪获得的PM10和PM2.5样品的来源，从而检测出八个来源。我们进一步结合了与交通相关的来源（刹车粉尘，汽车尾气和次要硝酸盐/有机物），以生成综合交通来源的指标。建立了逻辑回归模型以估计先兆子痫与整个孕期和孕中期分别暴露于各PM源和肿块之间的相关性，并针对相关协变量进行了调整。结果：对于整个妊娠期间的暴露，我们发现与IQR升高相关的先兆子痫风险增加44％（95％CI 7％至94％）和80％（95％CI 4％至211％）。分别暴露于PM10刹车粉尘和交通相关综合来源。使用替代的源分配方法（Multilinear Engine（ME2））后，这些发现保持一致。 PM2.5的质量和来源以及孕中期的暴露结果尚无定论。结论：先兆子痫的风险与暴露于PM10刹车粉尘和交通相关综合来源有关。

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