In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30 years following exposure. Michigan residents were enrolled in a study cohort after exposure to polybrominated biphenyls (PBBs) through the consumption of contaminated food products. PBB concentrations were measured in serum at the time of enrolment. Cancer experience was determined by linkage to the Michigan Cancer Registry. We conducted a nested case-control study that included 51 women diagnosed with breast cancer during 1974-2004 and 202 age-matched controls. While the data suggest an increase in breast cancer risk with higher PBB exposure, this did not reach statistical significance. The OR of having breast cancer among women with PBB concentrations >= 10 ng/mL compared to women with PBB concentrations at or below the limit of detection of 1 ng/mL was 2.60, 95% CI 0.93 to 7.27, (p=0.07), when adjusted for age and family history of cancer in a first-degree female relative. It remains important to examine exposure to brominated chemicals and possible health effects, and to continue following the cancer experience of participants in this study.
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机译：在这项最新的随访中，我们调查了密歇根州接触溴化阻燃剂的妇女大约30年后的乳腺癌经历。密歇根州居民因食用受污染的食品而暴露于多溴联苯（PBB）后被纳入研究队列。入组时在血清中测量PBB浓度。癌症经验是通过与密歇根州癌症登记处的联系来确定的。我们进行了一项嵌套的病例对照研究，该研究纳入了1974-2004年间被诊断患有乳腺癌的51位女性和202位年龄相匹配的对照。虽然数据表明较高的PBB暴露会增加患乳腺癌的风险，但这并未达到统计学意义。 PBB浓度> = 10 ng / mL的女性与PBB浓度等于或低于1 ng / mL的女性相比，患乳腺癌的OR为2.60，95％CI为0.93至7.27，（p = 0.07） ，根据一级女性亲戚的年龄和癌症家族史进行调整后。检查暴露于溴化化学物质和可能的健康影响，并继续关注本研究参与者的癌症经历仍然很重要。
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