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Occupational exposure to crystalline silica and gastric cancer: a systematic review and meta-analysis

机译：职业性接触结晶性二氧化硅和胃癌的系统评价和荟萃分析

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Crystalline silica is a widely used industrial material that is readily available worldwide, and is one of the most common types of particulate mineral pollutants. It has been classified as a group 1 human carcinogen of the respiratory system; however, whether it is linked to gastric cancer remains uncertain. We conducted a systemic review and meta-analyses to search for evidence of the relationship between gastric cancer and occupational exposure to crystalline silica. We searched for articles on occupations involving silica exposure and gastric cancer studies up to December 2014. Pooled-risk estimates of the association between occupational crystalline silica exposure and risk of gastric cancer were calculated by a random effects model. Metaregression analyses of industry type and histological confirmation status, study design and industrial subgroup analyses were performed. 29 articles, including 9 case-control and 20 cohort studies, were analysed. The overall summary effects size was 1.25 (95% CI 1.18 to 1.34) for the association of occupational silica exposure with gastric cancer. Both heterogeneity and publication bias were partially attenuated after subgroup analyses. Heterogeneity of studies was attenuated after metaregression by industry. Higher overall effects were observed in the mining and foundry industries. We found a significant relationship between occupational crystalline silica exposure and gastric cancer. Our results were strengthened by various subgroup analyses and, considering the biological plausibility of our premise, further studies are required to better understand this association.
机译：结晶二氧化硅是一种广泛使用的工业材料，已在世界范围内广泛使用，并且是最常见的颗粒状矿物污染物之一。它已被归类为呼吸系统的第一类人类致癌物。但是，它是否与胃癌有关尚不确定。我们进行了系统评价和荟萃分析，以寻找胃癌与职业性接触结晶二氧化硅之间关系的证据。我们搜索了直到2014年12月为止涉及二氧化硅暴露和胃癌研究的职业的文章。职业结晶二氧化硅暴露与胃癌风险之间的关联的汇总风险估计是通过随机效应模型计算的。进行了行业类型和组织学确认状态的元回归分析，研究设计和行业亚组分析。分析了29篇文章，包括9例病例对照研究和20项队列研究。对于职业性二氧化硅暴露与胃癌的相关性，总体总体影响大小为1.25（95％CI 1.18至1.34）。亚组分析后，异质性和发布偏倚均得到部分缓解。随着行业的元回归，研究的异质性减弱了。在采矿和铸造行业中观察到更高的总体效果。我们发现职业性结晶二氧化硅暴露与胃癌之间存在显着关系。我们的结果通过各种亚组分析得到了加强，考虑到我们前提的生物学可行性，需要进一步研究以更好地理解这种关联。

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