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Traffic-related air pollution and prostate cancer risk: A case-control study in Montreal Canada

机译：与交通有关的空气污染和前列腺癌的风险：加拿大蒙特利尔的一项病例对照研究

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Objectives There is a paucity of information on environmental risk factors for prostate cancer. We conducted a case-control study in Montreal to estimate associations with exposure to ground-level nitrogen dioxide (NO2), a marker for traffic-related air pollution. Methods Cases were 803 men with incident prostate cancer, ≤75 years of age, and diagnosed across all French hospitals in Montreal. Concurrently, 969 controls were drawn from electoral lists of French-speaking individuals residing in the same electoral districts as the cases and frequency-matched by age. Concentrations of NO2 were measured across Montreal in 2005-2006. We developed a land use regression model to predict concentrations of NO2 across Montreal for 2006. These estimates were back-extrapolated to 1996. Estimates were linked to residential addresses at the time of diagnosis or interview. Unconditional logistic regression was used, adjusting for potential confounding variables. Results For each increase of 5 parts per billion of NO2, as estimated from the original land use regression model in 2006, the OR5ppb adjusted for personal factors was 1.44 (95% CI 1.21 to 1.73). Adding in contextual factors attenuated the OR5ppb to 1.27 (95% CI 1.03 to 1.58). One method for back-extrapolating concentrations of NO2 to 1996 (about 10 years before the index date) gave the following OR5ppb: 1.41 (95% CI 1.24 to 1.62) when personal factors were included, and 1.30 (95% CI 1.11 to 1.52) when contextual factors were added. Conclusions Exposure to ambient concentrations of NO2 at the current address was associated with an increased risk of prostate cancer. This novel finding requires replication.
机译：目的缺乏关于前列腺癌的环境危险因素的信息。我们在蒙特利尔进行了一项病例对照研究，以估算与地面二氧化氮（NO2）接触的相关性，这是交通相关空气污染的标志。方法病例为803岁以下≤75岁的前列腺癌男性，在蒙特利尔的所有法国医院中均得到了诊断。同时，从与这些病例在同一选举区中居住的法语个人的选举名单中抽取了969个对照，并且按年龄进行频率匹配。在2005-2006年间，在蒙特利尔各地测量了NO2的浓度。我们开发了一个土地利用回归模型来预测2006年蒙特利尔的NO2浓度。这些估算值已回溯到1996年。这些估算值与诊断或访谈时的住所地址相关。使用无条件逻辑回归，调整潜在的混杂变量。结果根据2006年原始土地使用回归模型估算，每增加十亿分之5的NO2，经个人因素调整后的OR5ppb为1.44（95％CI为1.21至1.73）。加入上下文因素可将OR5ppb衰减至1.27（95％CI 1.03至1.58）。一种将NO2浓度反推至1996年（索引日期前约10年）的方法得出以下OR5ppb：包括个人因素时为1.41（95％CI 1.24至1.62），以及1.30（95％CI 1.11至1.52）。当添加上下文因素时。结论当前地址暴露于环境中的NO2浓度与患前列腺癌的风险增加有关。这个新发现需要复制。

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