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Exposure to organic solvents and personality.

机译：接触有机溶剂和个性。

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OBJECTIVES: Although cognitive and neuropsychological changes have been found after high cumulative exposures to solvents, it is not clear whether such exposures are associated with personality characteristics. To study this two groups of British and Chinese dockyard painters who had been heavily exposed to paint solvents have been investigated. METHODS: 260 Male dockyard painters in the United Kingdom, 539 local community controls, 109 Chinese dockyard painters, and 255 dockyard controls completed the Eysenck personality questionnaire, neuroticism (N) and social conformity or dissimulation (L) scales. The non-parametric Kruskal-Wallis test was used to evaluate differences in scores of personality traits between painters and controls. Adjusted relative risks for painters having high N and L scores were calculated in a Breslow-Cox regression analysis, and exposure-response relations were examined in multivariate logistic regression analysis. Non-parametric Spearman's correlation was used to examine relations between previously determined neuropsychological symptoms and personality. RESULTS: Both British and Chinese data showed that mean neuroticism scores of painters were significantly higher than controls, whereas scores of social conformity did not differ. Relative risk of being a painter increased significantly with increasing N scores, but L scores showed no such trend. In a case-control analysis, there were significant exposure-response relations for the N score. In the United Kingdom the odds ratios (ORs) (95% confidence interval (95% CI), were 2.03 (0.79 to 5.22) for 1-4 years of exposure, 2.38 (0.82 to 6.91) for 5-9 years, 7.05 (1.27 to 39.25) for 10-14 years, and 1.76 (0.63 to 4.89) for 15-41 years. In the Chinese painters, ORs were 4.66 (1.38 to 15.75) for 2-14 years, 10.03 (2.96 to 34.04) for 15-18 years, and 13.56 (3.78 to 48.59) for 19-43 years. Neuroticism was significantly positively related to neuropsychological symptoms in all subjects. Social conformity showed no association with neuropsychological symptoms in British painters and a negative relation among the Chinese painters. CONCLUSION: Increasing symptoms suggesting neuroticism seemed to relate to the duration of painting whereas scores for social conformity and dissimulation did not. The relation between exposure time and response suggests that increased neuroticism may be caused by long term occupational exposure to organic solvents.
机译：目的：尽管在大量累积接触溶剂后发现认知和神经心理学方面的变化，但尚不清楚此类接触是否与人格特征有关。为了研究这两组严重暴露于涂料溶剂中的英国和中国造船厂画家。方法：英国的260名男性造船厂画家，539位当地社区对照，109位中国造船厂画家和255个造船厂对照完成了艾森克人格问卷，神经质（N）和社会整合或轻视（L）量表。非参数Kruskal-Wallis检验用于评估画家与对照组之间人格特质得分的差异。在Breslow-Cox回归分析中计算了具有高N和L分数的画家的调整后相对风险，并在多元Logistic回归分析中检查了暴露-反应关系。非参数Spearman的相关性用于检查先前确定的神经心理学症状与人格之间的关系。结果：英国和中国的数据均表明，画家的神经质平均得分明显高于对照组，而社会整合得分没有差异。随着N分数的增加，成为画家的相对风险显着增加，但是L分数没有显示出这种趋势。在病例对照分析中，N得分存在显着的暴露-反应关系。在英国，暴露1至4年的几率（OR）（95％置信区间（95％CI），为2.03（0.79至5.22），5-9年为2.38（0.82至6.91），7.05（在10-14年内为1.27至39.25，在15-41年内为1.76（0.63至4.89）;在中国画家中，OR在2-14年内为4.66（1.38至15.75），10.03（2.96至34.04）为15结论：-18岁，13-56岁（3.78至48.59），19-43岁，神经质在所有受试者中均与神经心理学症状呈显着正相关;社交顺应性与英国画家的神经心理学症状无相关性，而中国画家之间则呈负相关。 ：增加的症状表明神经质似乎与绘画时间有关，而社交顺应性和侮辱性评分则与绘画时间无关，暴露时间与反应之间的关系表明，神经质增强可能是由于长期职业接触有机溶剂引起的。

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