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首页> 外文期刊>Occupational and environmental medicine >Estimation of cumulative exposure to organophosphate sheep dips in a study of chronic neurological health effects among United Kingdom sheep dippers.
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Estimation of cumulative exposure to organophosphate sheep dips in a study of chronic neurological health effects among United Kingdom sheep dippers.

机译：在对英国绵羊北斗星的慢性神经健康影响的研究中，估计了有机磷绵羊皮的累积暴露量。

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OBJECTIVES: To derive a method for retrospectively estimating cumulative exposure to organophosphate (OP) pesticides among a cross section of United Kingdom sheep dippers, as part of a wider epidemiological study of neurological abnormality within this group of workers. METHODS: A hygiene study of dipping sessions at 20 farms using diazinon based dips was carried out by two experienced occupational hygienists. Observations on the exposure of people to concentrate and dilute dip were recorded throughout each dipping session, together with the other relevant factors including the use and condition of protective clothing. Concentrations of urinary metabolites of diazinon were used to measure actual exposure to OPs. To estimate exposure in the subsequent epidemiological study, an occupational exposure history questionnaire was developed using results from the hygiene study and an empirical exposure model. RESULTS: In the hygiene study, increased urinary metabolites were associated with the handling of concentrate dip and exposure to dilute dip wash through splashing. Very few dippers wore the recommended protective clothing. The handling of concentrate dip was the principal source of exposure to OPs. Dipping task was used as a surrogate for splashing of dilute dip in retrospective exposure estimation. In the epidemiological study, cumulative exposure to OP sheep dips was highly correlated with the total number of dipping days, but not with age. CONCLUSIONS: Sheep dip concentrate is the most important source of OP exposure among sheep dippers and estimates of exposure to OPs during routine dipping should take due account of exposure to concentrate dip as well as to the dilute dip wash. The observed use of recommended protective clothing by most subjects was insufficient to allow a proper empirical assessment of its effectiveness.
机译：目的：推导一种方法来回顾性评估英国北斗七星各部门中有机磷（OP）农药的累积暴露，作为这一组工人神经系统异常流行病学研究的一部分。方法：由两名经验丰富的职业卫生学家对20个农场使用基于二嗪农的蘸水进行的蘸水会议进行了卫生研究。在每次浸洗过程中，均记录了人们对浓缩液和稀释浸液的暴露情况，并记录了其他相关因素，包括防护服的使用和状况。二嗪农的尿液代谢物浓度用于测量OP的实际暴露量。为了估计随后的流行病学研究中的暴露，使用卫生研究的结果和经验暴露模型开发了职业暴露历史问卷。结果：在卫生学研究中，尿液代谢产物的增加与浓缩液浸泡的处理以及通过溅水暴露于稀释浸泡液中有关。很少有北斗星穿着推荐的防护服。精矿浸的处理是OPs暴露的主要来源。在回顾性暴露评估中，浸渍任务被用作稀释稀释飞溅的替代物。在流行病学研究中，OP绵羊浸水的累积暴露与浸水天数的总数高度相关，但与年龄无关。结论：绵羊浸液是绵羊浸液中OP暴露的最重要来源，估计常规浸液中OP的暴露应适当考虑浓缩浸液和稀释浸液的暴露。大多数受试者观察到推荐的防护服的使用不足以对其有效性进行适当的经验评估。

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