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首页> 外文期刊>Occupational and environmental medicine >Cancer risk in offspring of male pesticide applicators in agriculture in Sweden.
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Cancer risk in offspring of male pesticide applicators in agriculture in Sweden.

机译：瑞典农业中男性施药后代的癌症风险。

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摘要

AIMS: To explore cancer risk from date of birth until 1994 in children, born 1958 or later, of Swedish male pesticide applicators. METHODS: Records of male pesticide applicators licensed 1965-76 were linked to the Multigeneration Register. The records of their offspring were then linked to the Swedish Cancer Registry and the Cause of Death Register. RESULTS: In total 51 cases of cancer were observed, which is significantly lower than the expected 73.0 (standardised incidence ratio (SIR) 0.70, 95% CI 0.52 to 0.92). Tumours of the nervous system was most common, amounting to 20 cases, 39% of all cancer cases (SIR 1.01, 95% CI 0.62 to 1.56). A statistically significant reduced risk for leukaemia was found (SIR 0.43, 95% CI 0.19 to 0.86). For non-Hodgkin's lymphoma, three cases were observed and 4.8 expected (SIR 0.63, 95% CI 0.13 to 1.83). For Hodgkin's disease, five cases were observed versus 3.7 expected (SIR 1.36, 95% CI 0.44 to 3.17). Two cases of testicular cancer were observed and 1.7 expected (SIR 1.19, 95% CI 0.13 to 4.28). CONCLUSIONS: None of the a priori hypotheses of increased risk of tumours of the nervous system, kidney cancer, leukaemia, lymphoma, soft tissue sarcoma, and testicular cancer in children of male pesticide applicators could be confirmed.
机译：目的：探讨瑞典男性男性施药者从1958年出生至1994年的出生日期至1994年的癌症风险。方法：1965-76年获得许可的男性农药施用者的记录与多代登记簿相关联。然后将其后代的记录链接到瑞典癌症登记处和死亡原因登记处。结果：总共观察到51例癌症，远低于预期的73.0（标准发生率（SIR）0.70，95％CI 0.52至0.92）。神经系统肿瘤最常见，共20例，占所有癌症病例的39％（SIR 1.01，95％CI 0.62至1.56）。发现白血病的统计学上显着降低的风险（SIR 0.43，95％CI 0.19至0.86）。对于非霍奇金淋巴瘤，观察到3例，预期为4.8（SIR为0.63，95％CI为0.13至1.83）。对于霍奇金病，观察到5例病例，而预期值为3.7（SIR 1.36，95％CI 0.44至3.17）。观察到两例睾丸癌，预期为1.7（SIR 1.19，95％CI 0.13至4.28）。结论：没有先验的假设可以证实男性农药施用儿童患神经系统肿瘤，肾癌，白血病，淋巴瘤，软组织肉瘤和睾丸癌的风险增加。

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