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首页> 外文期刊>Occupational and environmental medicine >Respiratory symptoms and cotton dust exposure; results of a 15 year follow up observation.
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Respiratory symptoms and cotton dust exposure; results of a 15 year follow up observation.

机译：呼吸道症状和接触棉粉尘; 15年随访观察的结果。

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AIMS: To determine chronic effects of long term exposure to cotton dust and endotoxin on incidence of respiratory symptoms and the effect of cessation of exposure. METHODS: Respiratory health in 429 Chinese cotton textile workers (study group) and 449 silk textile workers (control group) was followed prospectively from 1981 to 1996. Byssinosis, chest tightness, and non-specific respiratory symptoms were assessed by means of identical standardised questionnaires at four time points. Exposures to cotton dust and endotoxin were estimated using area samples collected at each survey. Incidence and persistence of symptoms were examined in relation to cumulative exposure and exposure cessation using generalised estimating equations (GEE). RESULTS: Among cotton workers, the cumulative incidence of byssinosis and chest tightness was 24% and 23%, respectively, and was significantly more common in smokers than in non-smokers. A high proportion of symptoms was found to be intermittent, rather than persistent. Among silk workers, no typical byssinosis was identified; the incidence of chest tightness was 10%. Chronic bronchitis, cough, and dyspnoea were more common and persistent in the cotton group than in the silk group. Significantly lower odds ratios for symptoms were observed in cotton workers who left the cotton mills; risk was also related to years since last worked. Multivariate analysis indicated a trend for higher cumulative exposure to endotoxin in relation to a higher risk for byssinosis. CONCLUSION: Chronic exposure to cotton dust is related to both work specific and non-specific respiratory symptoms. Byssinosis is more strongly associated with exposure to endotoxin than to dust. Cessation of exposure may improve the respiratory health of cotton textile workers; the improvement appears to increase with time since last exposure.
机译：目的：确定长期接触棉粉尘和内毒素对呼吸系统症状的发生和停止接触的影响。方法：从1981年至1996年，对429名中国棉纺织业工人（研究组）和449名丝绸纺织业工人（对照组）的呼吸健康状况进行了追踪调查。采用相同的标准化调查表评估了比虫病，胸闷和非特异性呼吸道症状。在四个时间点。使用每次调查收集的面积样本来估计棉尘和内毒素的暴露。使用广义估计方程（GEE）检查与累积暴露和暴露停止有关的症状发生率和持久性。结果：在棉工中，比虫病和胸闷的累积发生率分别为24％和23％，在吸烟者中比在不吸烟者中更为常见。发现很大一部分症状是间歇性的，而不是持久性的。在丝绸工人中，没有发现典型的byssinosis病。胸闷的发生率为10％。与丝绸组相比，棉组的慢性支气管炎，咳嗽和呼吸困难更为常见和持续。在离开棉纺厂的棉花工人中，观察到的症状发生几率明显降低。风险也与上次工作以来的年数有关。多变量分析表明与内毒素增多的风险相比，内毒素累积暴露的趋势更高。结论：长期接触棉尘与工作特异性和非特异性呼吸道症状有关。比起粉尘，比虫病与内毒素的暴露更紧密相关。停止接触可改善棉纺织工人的呼吸健康;自上次曝光以来，改善似乎随着时间的增加而增加。

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