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首页> 外文期刊>Occupational and environmental medicine >Can salivary lead be used for biological monitoring of lead exposed individuals?
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Can salivary lead be used for biological monitoring of lead exposed individuals?

机译：唾液中的铅可以用于铅暴露者的生物监测吗？

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BACKGROUND: Measurement of blood lead (BPb) is the usual method for biomonitoring of persons exposed to inorganic lead. AIM: To explore the use of salivary lead (SPb) as an alternative. METHODS: BPb and SPb levels were measured in a group of 82 lead exposed adults. RESULTS: The mean BPb of the workers was 26.6 microg/dl (SD 8.6, range 10-48) and the mean SPb level 0.77 microg/dl, or 3% of the BPb level. As the SPb distribution was skewed, logarithmic transformation was performed to normalise the distribution. A bivariate scattergram of BPb and logSPb (r = 0.41, p = 0.00) had a line of best fit expressed as BPb = 29.7 + 8.95logSPb. The relation of logSPb and BPb was stronger among non-smokers (r = 0.42) compared to smokers (r = 0.3); and among those without a medical condition (r = 0.44). Multiple linear regression analysis (fitting smoking and medical condition into the model) yielded an R of 0.54, and an adjusted R(2) of 0.26. CONCLUSION: The study findings do not support the use of SPb for biomonitoring at BPb levels ranging from 10 to 50 microg/dl.
机译：背景：血铅（BPb）的测量是对暴露于无机铅的人进行生物监测的常用方法。目的：探讨唾液铅（SPb）的替代方法。方法：在一组82名铅暴露成人中测量了BPb和SPb水平。结果：工人的平均BPb为26.6微克/分升（标准差8.6，范围10-48），平均SPb水平为0.77微克/分升，占BPb水平的3％。当SPb分布偏斜时，执行对数转换以标准化分布。 BPb和logSPb的双变量散点图（r = 0.41，p = 0.00）的最佳拟合线表示为BPb = 29.7 + 8.95logSPb。与吸烟者（r = 0.3）相比，非吸烟者（r = 0.42）中logSPb和BPb的关系更强。在没有健康状况的人群中（r = 0.44）。多元线性回归分析（将吸烟和医疗状况纳入模型）得出的R为0.54，调整后的R（2）为0.26。结论：研究结果不支持使用SPb进行BPb水平从10到50 microg / dl的生物监测。

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