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首页> 外文期刊>Occupational and environmental medicine >Mortality from lung cancer and population risk attributable to asbestos in an asbestos cement manufacturing town in Italy.
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Mortality from lung cancer and population risk attributable to asbestos in an asbestos cement manufacturing town in Italy.

机译：意大利石棉水泥制造镇的肺癌死亡率和石棉可导致的人口风险。

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OBJECTIVE: To estimate mortality from lung cancer and the risk attributable to asbestos separately for asbestos cement workers and for the general (non-occupationally exposed) population in the town of Casale Monferrato, where the largest Italian asbestos cement factory had been in operation in 1907-86. According to cancer registry data, in the same town the incidence of malignant mesothelioma in the general population is about 10 times higher than in comparable Italian provinces. METHOD: Decedents from lung cancer in 1989-95 were nominally identified in the list of decedents kept at the Local Health Authority of Casale Monferrato. Workers in the asbestos cement factory have been identified with a search in the nominal list of workers and the same was done for the wives of asbestos cement workers. These lists have already been used in cohort studies. Sensitivity and specificity of the linkage procedure with occupational activity in asbestos cement production have been evaluated in a previous study. Population at risk was estimated on the basis of official figures and on the results of the cohort study of asbestos cement workers. RESULTS: 227 deaths from lung cancer were included (184 men and 43 women). Among the asbestos cement workers mortalities were 234.0 x 100,000 person-years among men and 35.5 among women. Corresponding figures in the general (non-occupationally exposed) population in Casale Monferrato were 80.6 and 18.7. The rates in the general population were not higher than in the rest of the region. Attributable risk (AR) among the asbestos cement workers (and wives) is 67.5% (95% confidence interval (95% CI) 56.8 to 78.2) for men and 51.3% (95% CI 14.9 to 87.8) among women. Population AR to occupational or paraoccupational exposure in the asbestos cement production is 18.3% (95% CI 11.1 to 25.6) among men and 10.1% (95% CI 0 to 24.6) among women. CONCLUSION: This work did not show an increase in mortality from lung cancer for the population not exposed occupationally, but a large excess was found among men and women occupationally exposed in asbestos cement production. The total burden of lung cancer due to occupational exposure to asbestos may be underestimated, as only occupational exposure in asbestos cement production was taken into consideration. Nevertheless even a single factory can be responsible for a considerable proportion of deaths from lung cancer in a population.
机译：目的：估算卡萨莱蒙费拉托镇的肺癌死亡率和石棉水泥工人以及一般（非职业接触）人口的石棉风险，该镇是最大的意大利石棉水泥工厂于1907年投入运营的地方-86。根据癌症登记处的数据，在同一城镇，一般人群中恶性间皮瘤的发病率约为意大利同类省份的10倍。方法：1989-95年间肺癌的后代在名义上被确定为Casale Monferrato当地卫生局保存的死者名单。在石棉水泥厂的工人中，已经在名义上的工人名单中进行了搜索，而对石棉水泥工的妻子也是如此。这些列表已被用于队列研究。在先前的研究中已经评估了连接过程与职业活动在石棉水泥生产中的敏感性和特异性。根据官方数字和石棉水泥工人的队列研究结果，估计有危险的人口。结果：包括227例肺癌死亡（184例男性和43例女性）。在石棉水泥工人死亡率中，男性为2​​34.0 x 100,000人年，女性为35.5。 Casale Monferrato的一般（非职业暴露）人口中的相应数字是80.6和18.7。普通人群中的患病率不高于该地区其他地区。石棉水泥工人（和妻子）的归因风险（AR）为男性为67.5％（95％置信区间（95％CI）为56.8至78.2），女性为51.3％（95％CI为14.9至87.8）。在男性和女性中，石棉水泥生产中职业或副职业暴露的人口AR为18.3％（95％CI 11.1至25.6），女性为10.1％（95％CI 0至24.6）。结论：这项工作并未显示未职业接触人群的肺癌死亡率增加，但是在石棉水泥生产中职业暴露的男性和女性中发现大量增加。由于只考虑了石棉水泥生产中的职业暴露，因此可能低估了由于职业性接触石棉引起的肺癌总负担。然而，即使是一家工厂，也可能导致人口中相当一部分死于肺癌的死亡。

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