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首页> 外文期刊>Occupational and environmental medicine >Case-control study of leatherwork and male infertility.
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Case-control study of leatherwork and male infertility.

机译：皮革制品和男性不育的病例对照研究。

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OBJECTIVES: To test the hypothesis that leatherwork is associated with male infertility mediated through the development of oligozoospermia. The basis of any association was postulated, at the outset, to be with exposure to the solvents used in leatherwork. METHODS: All new referrals with infertility presenting in Leicestershire hospital clinics between November 1988 and September 1992 and Kettering District General Hospital from August 1990 were eligible to participate; 88.5% agreed to be interviewed. Exposure to leatherwork and work with solvents was defined by job title. Comparisons were made with fertile controls and in an analysis within men from infertile couples with oligozoospermia as the primary outcome. Effects on sperm motility and deformity were investigated secondarily. Analyses used logistic regression for binary outcomes and multilevel modelling for continuous outcomes. RESULTS: 1906 men were interviewed. Compared with the fertile controls the men from infertile couples were 1.10 times (95% confidence interval (95% CI) 0.46 to 2.63; p=0.99) more likely to be leatherworkers and 1.73 times (95% CI 1.26 to 2.38; p<0.001) more likely to work with solvents. Compared with other men, leatherworkers were 1.20 times (95% CI 0.43 to 3.33; p=0.73) more likely to present with oligozoospermia and 1.65 times (95% CI 0.37 to 7.30; p=0.51) more likely to present with teratozoospermia. Being a leatherworker was associated with only a 6% reduction in sperm concentration; motility and deformity were similarly unaffected by this exposure. Work with solvents did not statistically, nor clinically, increase the risk of oligozoospermia, teratozoospermia, or asthenozoospermia. CONCLUSIONS: There was little evidence to support the hypothesis that leatherwork is associated with an increased risk of presenting with infertility or oligozoospermia. There was limited evidence that leatherwork is a risk factor for teratozoospermia. Workers with solvents were at an increased risk of presenting with infertility, although this was not mediated through effects on standard measures of semen quality; this finding merits further investigation.
机译：目的：检验皮革制品与通过少精症发展所介导的男性不育有关的假设。首先假定任何关联的基础是与皮革制品中使用的溶剂接触。方法：1988年11月至1992年9月在莱斯特郡医院诊所和1990年8月开始在凯特林区总医院就诊的所有新的不育症转诊患者均符合参加资格; 88.5％同意接受采访。皮革工作和使用溶剂的工作由职务定义。用可育对照进行比较，并在不育夫妇中以少精子症为主要结果的男性进行分析。其次研究了对精子活力和畸形的影响。分析使用对数结果进行逻辑回归，对连续结果进行多级建模。结果：1906名男性接受了采访。与受精对照相比，不育夫妇的皮革工人更有可能是男性的1.10倍（95％置信区间（95％CI）为0.46至2.63; p = 0.99）和1.73倍（95％CI为1.26至2.38; p <0.001） ）更可能与溶剂一起使用。与其他男性相比，皮革工人出现少精症的可能性高1.20倍（95％CI为0.43至3.33; p = 0.73），而畸胎症的发生率则为1.65倍（95％CI为0.37至7.30; p = 0.51）。作为制皮工，精子浓度只降低6％。类似地，运动和畸形也不受这种暴露的影响。使用溶剂进行的工作在统计学上和临床上均未增加少精症，畸胎症或弱精子症的风险。结论：几乎没有证据支持这一假设，即皮革制品与不孕症或少精症的风险增加有关。仅有有限的证据表明皮革制品是畸形精子症的危险因素。使用溶剂的工人出现不孕症的风险增加，尽管这不是通过对精液质量标准方法的影响来介导的。这一发现值得进一步调查。

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