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首页> 外文期刊>Occupational and environmental medicine >Risk of leukaemia among children living near the Solway coast of Dumfries and Galloway Health Board area, Scotland, 1975-2002.
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Risk of leukaemia among children living near the Solway coast of Dumfries and Galloway Health Board area, Scotland, 1975-2002.

机译：1975-2002年，苏格兰邓弗里斯和盖洛韦卫生局地区索尔韦海岸附近儿童的白血病风险。

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OBJECTIVE: To investigate allegations of an excess risk of leukaemia among children living near the Solway Firth coast of Dumfries and Galloway Health Board area in Scotland, UK. METHODS: Incident cases of childhood leukaemia (International Classification of Diseases, 10th revision, C91-C95, patients aged 0-14 years) for two almost equal calendar periods of diagnosis (1975-89 and 1990-2002) were selected from the Scottish Cancer Registry database and allocated to predetermined study areas, on the basis of proximity of residence to the Solway coast. Expected numbers of childhood leukaemia cases for the study areas were calculated by applying Scotland's age-specific, sex-specific and calendar period-specific rates to estimates of the person-years at risk in each study area. The ratios of observed to expected cases or standardised incidence ratios (SIRs) were calculated overall and for each sex and calendar period category. Exact 95% confidence intervals (CIs) for the SIRs were calculated assuming a Poisson distribution for the observed number of cases of childhood leukaemia. RESULTS: No statistically significantly increased SIRs were found in boys, girls or both combined for any of the areas or periods of diagnosis studied. For the total period of observation (1975-2002), and the more immediate coastal area studied, the SIR for both sexes combined was 1.22 (95% CI 0.53 to 2.40). CONCLUSION: No statistically significant evidence was found of an excess risk of childhood leukaemia in the vicinity of the Solway Firth coast of Dumfries and Galloway Health Board area in Scotland.
机译：目的：调查居住在英国苏格兰邓弗里斯索威峡湾海岸和盖洛韦卫生局附近儿童的白血病风险过高的指控。方法：从苏格兰癌症中选择两个几乎相同的诊断日历期（1975-89年和1990-2002年）的儿童白血病（国际疾病分类，第10版，C91-C95，0-14岁的患者）突发事件。登记数据库，并根据居住地与Solway海岸的距离分配给预定的研究区域。通过将苏格兰的特定年龄，特定性别和特定日历时期的比率应用于每个研究区域中高危人群的估计数，可以计算出研究区域儿童白血病的预期数量。总体上针对每个性别和日历时期类别，计算观察到的病例与预期病例的比率或标准发生率（SIR）。假设观察到的儿童白血病病例数为泊松分布，则计算出SIR的准确95％置信区间（CI）。结果：在所研究的诊断的任何区域或期间，在男孩，女孩或两者中未发现SIR的统计学显着增加。在整个观察期间（1975年至2002年）以及更近的沿海地区，两性的SIR总计为1.22（95％CI为0.53至2.40）。结论：在苏格兰邓弗里斯的索尔维峡湾海岸和盖洛韦卫生局附近，没有统计学上的证据表明儿童患白血病的风险过高。

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