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首页> 外文期刊>Occupational and environmental medicine >Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

机译：评估暴露于2,3,7,8-四氯二苯并-对-二恶英的美国工人的糖尿病，血糖和甲状腺功能。

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OBJECTIVE: Some studies suggest that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may affect glucose metabolism and thyroid function. To further assess the relation between exposure to TCDD and endocrine function, data from the largest morbidity study of industrial workers exposed to TCDD were examined. METHODS: A cross sectional study of workers employed > 15 years earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two United States chemical plants was conducted. The referent group consisted of people with no occupational exposure to phenoxy herbicides and were recruited from the neighbourhoods where the workers lived. RESULTS: A total of 281 workers and 260 unexposed referents participated. The mean current serum lipid adjusted TCDD concentration among workers was 220 pg/g lipid, and among referents was 7 pg/g lipid (p < 0.05). The half life extrapolated TCDD concentrations (the estimated TCDD concentration when occupational exposure to TCDD stopped) among workers averaged 1900 pg/g lipid (range: not detected--30,000 pg/g lipid). Overall, the prevalence of diabetes mellitus was not significantly different between the workers and referents. Also, there was not a significant positive trend between prevalence of diabetes and increasing serum TCDD concentration. However, diabetes was found in six of 10 (60%) workers with current serum TCDD concentrations > 1500 pg/g lipid. After excluding subjects being treated for diabetes, workers in the group with the highest half life extrapolated TCDD concentrations had a significantly increased adjusted mean serum glucose concentration compared with referents (p = 0.03). Workers were also found to have a significantly higher adjusted mean free thyroxine index compared with referents (p = 0.02), especially among workers in the group with the highest half life extrapolated TCDD concentrations. However, no evidence was found that workers exposed to TCDD were at increased risk of thyroid disease. CONCLUSIONS: These findings provide modest evidence that exposure to TCDD may affect thyroid function and glucose metabolism.
机译：目的：一些研究表明，接触2,3,7,8-四氯二苯并-对-二恶英（TCDD）可能会影响葡萄糖代谢和甲状腺功能。为了进一步评估TCDD暴露与内分泌功能之间的关系，对来自TCDD暴露的最大工业发病率研究数据进行了检查。方法：进行了一项横截面研究，对在美国两家化学工厂生产2,4,5-三氯苯酚或其中一种衍生物的雇用时间超过15年的工人进行了研究。推荐人群由没有职业性接触苯氧基除草剂的人员组成，是从工人居住的社区招募的。结果：共有281名工人和260名未暴露的推荐人参加。工人中目前平均血清脂质调节的TCDD浓度为220 pg / g脂质，而参考对象中为7 pg / g脂质（p <0.05）。工人的半衰期外推TCDD浓度（当职业性接触TCDD停止时的估计TCDD浓度）平均为1900 pg / g脂质（范围：未检测到30,000 pg / g脂质）。总体而言，工人和参考对象之间的糖尿病患病率没有显着差异。而且，在糖尿病患病率与血清TCDD浓度增加之间也没有明显的积极趋势。但是，在当前血清TCDD浓度> 1500 pg / g脂质的10名工人中，有6名（60％）发现了糖尿病。在排除接受糖尿病治疗的对象后，半衰期外推的TCDD浓度最高的组的工人的平均调整血糖浓度与参考人相比有显着增加（p = 0.03）。还发现工人的平均游离甲状腺素水平比参考对象高得多（p = 0.02），尤其是半衰期最高的TCDD浓度人群中。但是，没有证据表明接触TCDD的工人患甲状腺疾病的风险增加。结论：这些发现提供了适度的证据，表明接触TCDD可能影响甲状腺功能和葡萄糖代谢。

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