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首页> 外文期刊>Occupational and environmental medicine >Modulating influence of cytochrome P-450 MspI polymorphism on serum liver function profiles in coke oven workers.
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Modulating influence of cytochrome P-450 MspI polymorphism on serum liver function profiles in coke oven workers.

机译：调节细胞色素P-450 MspI多态性对炼焦炉工人血清肝功能谱的影响。

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OBJECTIVES: It was reported previously that topside oven workers with heavy exposure to coke oven emissions had increased serum activities of hepatic aminotransferase in one coke oven plant. This study was conducted to investigate the modifying effect of CYP1A1 MspI polymorphism on liver function profiles in coke oven workers. METHODS: 88 coke oven workers from a large steel company in Taiwan were studied in 1995-6. Exposure was categorised by work area: topside oven workers and sideoven workers. Liver function profiles including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), r-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin (BIL) were examined in the morning after personal exposure measurements. The MspI polymorphism was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS: Five of 23 (22%) topside oven workers and seven of 65 (11%) sideoven workers had the CYP1A1 MspI homozygous variant genotype. With sideoven workers with the combined wild type and heterozygous variant as the reference group in multiple regression models, it was found that topside oven workers with the combined traits had mean AST and ALT activities that were 21% and 46% higher (95% confidence interval (95% CI) 4% to 42% and 12% to 91%, respectively) than the reference group after adjusting for appropriate confounders. Also, topside oven workers with the homozygous variant trait had mean AST, ALT, and GGT activities that were 59%, 68%, and 157% higher (95% CI 21% to 109%, 6% to 168%, and 39% to 374%, respectively) than the reference group. The prevalence of an abnormal hepatocellular pattern (AST > 37 IU/l or ALT > 39 IU/l) was more common in the topside oven workers with the homozygous variant than in the sideoven workers with the other combined genotypes (adjusted odds ratio 9.9, 95% CI 1.2 to 82.3) after adjusting for appropriate confounders. CONCLUSIONS: The CYP1A1 MspI polymorphism may modify the biotransformation of coke oven emissions, which results in hepatocellular damage in coke oven workers.
机译：目的：以前有报道说，在一家焦炉厂中，大量接触焦炉排放物的上层烤箱工人增加了肝氨基转移酶的血清活性。进行这项研究以研究CYP1A1 MspI基因多态性对炼焦炉工人肝功能谱的影响。方法：1995-6年对来自台湾一家大型钢铁公司的88名焦炉工人进行了研究。暴露按工作区域分类：上烤箱工人和烤炉工人。在个人暴露测量后的早晨检查了肝功能，包括血清天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），r-谷氨酰转肽酶（GGT），碱性磷酸酶（ALP）和总胆红素（BIL）。通过聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）确定MspI多态性。结果：23名顶面烤箱工人中有5名（22％）和65名烤箱工人（11％）中有7名具有CYP1A1 MspI纯合子变异基因型。在多个回归模型中，将具有野生型和杂合性变体组合的烤架工人作为参考组，发现具有组合特征的顶面烤箱工人的平均AST和ALT活性分别高21％和46％（95％置信区间（95％CI）分别调整为适当的混杂因素后比参考组高4％至42％和12％至91％。此外，具有纯合变异性状的炉顶烤箱工人的平均AST，ALT和GGT活性分别高59％，68％和157％（95％CI 21％至109％，6％至168％和39％ （分别为374％）。与纯合子变异的顶面烤箱工人相比，杂合烤箱工人的肝细胞形态异常（AST> 37 IU / l或ALT> 39 IU / l）的患病率比其他组合基因型的侧烤箱工人（调整比值比为9.9，调整为适当的混杂因素后，CI为95％CI 1.2至82.3）。结论：CYP1A1 MspI多态性可能会改变焦炉排放物的生物转化，导致焦炉工人肝细胞受损。

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