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首页> 外文期刊>Occupational and environmental medicine >Occupational risk factors for prostate cancer and benign prostatic hyperplasia: a case-control study in Western Australia.
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Occupational risk factors for prostate cancer and benign prostatic hyperplasia: a case-control study in Western Australia.

机译：前列腺癌和前列腺增生的职业危险因素：西澳大利亚州的病例对照研究。

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OBJECTIVE: To assess the association of selected occupational exposures with risk of prostate cancer and with risk of benign prostatic hyperplasia (BPH). METHODS: This population-based case-control study recruited 606 men with a diagnosis of confirmed prostate cancer, 400 men who had undergone their first prostatectomy for BPH and 471 male controls randomly selected from the electoral roll between 1 August 2001 and 1 October 2002 in Western Australia. chi(2) tests and logistic regressions were used for univariate and multivariate analyses to investigate the association of the two outcomes with occupational exposure to pesticides, fertilisers, metals, wood dust, oils, diesel exhaust and polyaromatic hydrocarbons (PAHs). RESULTS: Exposure to toxic metals at a non-substantial level increased the risk of BPH (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.1 to 1.84) and led to a non-significant excess risk of prostate cancer (OR 1.25, 95% CI 0.96 to 1.61). Non-significant excess risks were observed for prostate cancer after exposure to oils other than mineral oil (OR 1.54, 95% CI 0.95 to 2.51) and for BPH after exposure to PAHs (OR 1.20, 95% CI 0.91 to 1.58). A non-statistically significant protective effect for prostate cancer was seen after exposure to organophosphate pesticides (OR 0. 69, 95% CI 0.43 to 1.12). No other associations were found for either prostate cancer or BPH and no dose-response relationships were seen for the exposures investigated. CONCLUSIONS: These results do not provide evidence that any of the occupational factors examined are risk factors for either prostate cancer or BPH.
机译：目的：评估某些职业暴露与前列腺癌风险和良性前列腺增生（BPH）风险之间的关系。方法：这项基于人群的病例对照研究共招募了606名诊断为确诊前列腺癌的男性，400名接受了BPH首次前列腺切除术的男性和471名从2001年8月1日至2002年10月1日在选举册中随机选择的男性对照组。澳洲西部。使用chi（2）测试和logistic回归进行单变量和多变量分析，以调查两种结果与职业性接触农药，化肥，金属，木屑，油，柴油机废气和多环芳烃（PAHs）的关系。结果：以非实质性水平接触有毒金属会增加BPH的风险（比值比（OR）1.39，95％置信区间（CI）1.1至1.84），并导致前列腺癌的非显着过高风险（OR 1.25，95％CI 0.96至1.61）。暴露于除矿物油以外的其他油后，前列腺癌的风险不显着（OR 1.54，95％CI 0.95至2.51），而暴露于PAHs的BPH（OR 1.20，95％CI 0.91至1.58）。暴露于有机磷酸盐杀虫剂后，前列腺癌的保护作用无统计学意义（OR 0. 69，95％CI 0.43至1.12）。没有发现前列腺癌或前列腺增生症的其他关联，并且所研究的暴露量均未发现剂量反应关系。结论：这些结果没有提供证据表明所检查的任何职业因素都是前列腺癌或前列腺增生的危险因素。

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