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首页> 外文期刊>Occupational and environmental medicine >Mortality study update of acrylamide workers.
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Mortality study update of acrylamide workers.

机译：丙烯酰胺工人的死亡率研究更新。

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OBJECTIVE: The authors examined the long-term health effects of occupational exposure to acrylamide among production and polymerisation workers. METHODS: An earlier study of 371 acrylamide workers was expanded to include employees hired since 1979. In this updated study, 696 acrylamide workers were followed from 1955 through 2001 to ascertain vital status and cause of death. Exposure to acrylamide was retrospectively assessed based on personal samples from the 1970s onwards and area samples over the whole study period. RESULTS: Fewer of the acrylamide workers died (n = 141) compared to an expected number of 172.1 (SMR 81.9, 95% CI 69.0 to 96.6). No cause-specific SMR for any of the investigated types of cancer was exposure related. The authors did, however, find more pancreatic cancer deaths than expected (SMR 222.2, 95% CI 72.1 to 518.5). With respect to non-malignant disease, more diabetes deaths were observed than expected (SMR 288.7, 95% CI 138.4 to 531.0). To assess the influence of regional factors, the analysis was repeated with an internal reference population. The elevated SMR for diabetes persisted. CONCLUSION: This study provides little evidence for a cancer risk from occupational exposure to acrylamide at production facilities. However, the increased rates of pancreatic cancer in this study and another larger study of acrylamide production workers indicate that caution is needed to rule out a cancer risk. The authors believe that the excess of diabetes mortality in this study is most likely not related to acrylamide exposure, because a larger study of acrylamide workers reported a deficit in this cause of death. The authors conclude that the increased SMR for diabetes mortality is probably not related to regional influences.
机译：目的：作者研究了生产和聚合工人对丙烯酰胺职业接触的长期健康影响。方法：一项对371名丙烯酰胺工作人员的早期研究已扩展至自1979年以来雇用的雇员。在此更新的研究中，从1955年到2001年随访了696名丙烯酰胺工作人员，以确定生命状况和死亡原因。根据1970年代以后的个人样本以及整个研究期间的区域样本，对丙烯酰胺的暴露进行了回顾性评估。结果：与预期的172.1（SMR 81.9，95％CI 69.0至96.6）相比，更少的丙烯酰胺工人死亡（n = 141）。没有任何原因相关的SMR与所研究的任何癌症类型相关。然而，作者确实发现胰腺癌死亡人数比预期多（SMR 222.2，95％CI 72.1至518.5）。关于非恶性疾病，观察到的糖尿病死亡人数比预期的多（SMR 288.7，95％CI 138.4至531.0）。为了评估区域因素的影响，对内部参考人群进行了重复分析。糖尿病患者的SMR持续升高。结论：这项研究几乎没有证据表明在生产设施中职业性接触丙烯酰胺会致癌风险。但是，在这项研究和另一项较大的丙烯酰胺生产工人研究中，胰腺癌的发病率上升表明需要谨慎行事，以排除癌症风险。作者认为，这项研究中糖尿病死亡率过高很可能与丙烯酰胺暴露无关，因为对丙烯酰胺工人进行的一项更大的研究报告了这种死亡原因的不足。作者得出结论，糖尿病死亡率的SMR升高可能与区域影响无关。

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