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首页> 外文期刊>Occupational and environmental medicine >Spreading of occupational allergens: laboratory animal allergens on hair-covering caps and in mattress dust of laboratory animal workers.
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Spreading of occupational allergens: laboratory animal allergens on hair-covering caps and in mattress dust of laboratory animal workers.

机译：职业性过敏原的传播：在覆盖动物的帽子和实验动物工作者的床垫灰尘中的实验动物过敏原。

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BACKGROUND: Family members of laboratory animal workers are at risk of developing allergy to laboratory animals. Little is known about the spreading of laboratory animal allergens outside the animal facilities. OBJECTIVE: To assess the presence of laboratory animal allergens in dust collected from mattresses of laboratory animal workers and unexposed controls. METHODS: Mouse and rat urinary proteins were measured in samples of mattress dust collected by laboratory animal workers and unexposed controls. In addition, rat and mouse allergens were determined in extracts of hair-covering caps, used during laboratory animal work, to estimate spreading of allergen through dust captured on hair. Allergen concentrations on hair caps were compared with exposure measured by personal airborne dust sampling. RESULTS: Levels of rat urinary allergens (RUA) and mouse urinary allergens (MUA) and mouse urinary protein (MUP) 8, a specific pheromone-binding mouse allergen, were significantly higher in mattress samples of laboratory animal workers than in those of controls. Hair-covering caps used in animal facilities harboured large amounts of RUA and MUA, which correlated significantly with exposure measured by the personal sampling technique in the animal facility. CONCLUSIONS: Occupational laboratory animal allergens are detectable in mattress dust of laboratory animal workers. Transfer of allergens via uncovered hair of animal workers is likely contributing to this phenomenon. This study stresses the importance of using hair caps to prevent spreading of occupational allergens.
机译：背景：实验动物工作者的家庭成员有对实验动物过敏的风险。关于实验室动物过敏原在动物设施外的传播知之甚少。目的：评估从实验动物工作人员的床垫和未暴露的对照中收集的灰尘中是否存在实验动物过敏原。方法：在实验动物工作者和未暴露的对照组收集的床垫灰尘样品中测量小鼠和大鼠的尿蛋白。此外，在实验室动物工作期间使用的覆盖头发的帽子提取物中确定了大鼠和小鼠的过敏原，以估计过敏原通过捕获在头发上的灰尘扩散。将头发帽上的过敏原浓度与通过个人空气尘埃采样测量的暴露量进行比较。结果：实验动物工作者的床垫样品中大鼠尿液过敏原（RUA），小鼠尿液过敏原（MUA）和小鼠尿液蛋白（MUP）8的水平显着高于对照组。动物设施中使用的毛发遮盖帽包含大量RUA和MUA，这与通过动物设施中的个人采样技术测得的暴露量显着相关。结论：在实验动物工作者的床垫灰尘中可检测到职业实验动物过敏原。通过未暴露的动物工作者的头发转移过敏原很可能是造成这种现象的原因。这项研究强调使用发帽防止职业过敏原扩散的重要性。

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