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首页> 外文期刊>Occupational and environmental medicine >A prospective cohort study of exposure-response relationship for vibration-induced white finger.
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A prospective cohort study of exposure-response relationship for vibration-induced white finger.

机译：前瞻性队列研究振动诱发白手指的暴露-反应关系。

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OBJECTIVES: To investigate prospectively the relation between vibration-induced white finger (VWF) and measures of cumulative (lifetime) exposure to hand-transmitted vibration (HTV). METHODS: Two hundred and forty-nine HTV workers and 138 control men of the same companies participated in a 3-year follow-up study. The diagnosis of VWF (Raynaud's phenomenon in the controls) was based on the medical history, the administration of colour charts and the results of a cold test. Tool vibration magnitudes were expressed as root-mean-square (r.m.s.) acceleration, frequency-weighted according to international standard ISO 5349-1 and also unweighted over the frequency range 6.3-1250 Hz. From the vibration magnitudes and exposure durations, alternative measures of cumulative vibration dose were calculated for each HTV worker, according to the expression: dose = Sigmaa(i)(m)t(i), where a(i) is the acceleration magnitude on tool i, t(i) is the lifetime exposure duration (hours) for tool i, and m = 0, 1, 2 or 4. RESULTS: The incidence of VWF varied from 5 to 6% in the HTV workers versus 0 to 1.5% for Raynaud's phenomenon in the controls. After adjusting for potential confounders, measures of cumulative vibration dose derived from total operating hours and high powers of unweighted acceleration (ie, , with m>1) gave better predictions of the occurrence of VWF than dose measures calculated from frequency-weighted acceleration (ie, ). These findings were observed in the entire sample of HTV workers, in those with no VWF at the initial investigation, and in those with normal cold test results at baseline. CONCLUSIONS: This prospective cohort study suggests that measures of cumulative vibration doses constructed from unweighted r.m.s. acceleration perform better for the prediction of VWF than dose measures calculated according to the recommendations of current standards. These findings should contribute to the improvement of the ISO frequency weighting for evaluating the severity of hand-transmitted vibration.
机译：目的：前瞻性研究振动诱发的白手指（VWF）与手传播的振动（HTV）累积（寿命）暴露量度之间的关系。方法：同一公司的249名HTV工人和138名控制人员参加了为期3年的随访研究。 VWF（对照中的雷诺现象）的诊断是基于病史，比色表的管理和感冒试验的结果。刀具振动幅度表示为均方根（r.m.s.）加速度，根据国际标准ISO 5349-1进行频率加权，并且在6.3-1250 Hz的频率范围内未加权。从振动幅度和暴露持续时间，根据以下表达式计算每个HTV工人的累积振动剂量的替代度量：剂量= Sigmaa（i）（m）t（i），其中a（i）是加速度工具i，t（i）是工具i的寿命暴露时间（小时），m = 0、1、2或4。结果：HTV工人的VWF发生率从5％到6％不等，从0到1.5不等。控件中Raynaud现象的百分比。在对潜在的混杂因素进行调整之后，与从频率加权的加速度（即，m> 1）得出的剂量测量值相比，从总运行时间和未加权加速度的大功率（即，m> 1）得出的累积振动剂量的测量值可以更好地预测VWF的发生。 ，）。在所有HTV工人样本中，初次调查中没有VWF的人以及基线时冷测试结果正常的人中都观察到了这些发现。结论：这项前瞻性队列研究表明，未加权r.m.s.与根据当前标准的建议计算的剂量测量相比，加速对VWF的预测效果更好。这些发现应有助于改善ISO频率加权，以评估手传递振动的严重性。

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