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首页> 外文期刊>Occupational and environmental medicine >Occupational exposure to trichloroethylene and perchloroethylene and the risk of lymphoma, liver, and kidney cancer in four Nordic countries.
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Occupational exposure to trichloroethylene and perchloroethylene and the risk of lymphoma, liver, and kidney cancer in four Nordic countries.

机译：在四个北欧国家中，三氯乙烯和四氯乙烯的职业接触以及淋巴瘤，肝癌和肾癌的风险。

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Trichloroethylene (TCE) and Perchloroethylene (PER) are two chlorinated solvents that are applied widely as degreasers of metal parts, and in dry cleaning and other applications. In 2012, the International Agency for Research on Cancer classified TCE as carcinogenic to humans and PER as probably carcinogenic to humans. We explored exposure-response relations for TCE and PER and non-Hodgkin's lymphoma (NHL), multiple myeloma (MM), and cancers of the kidney and liver in the Nordic Occupational Cancer cohort.The cohort was set up by linking occupational information from censuses to national cancer registry data using personal identity codes in use in all Nordic countries. Country, time period, and job-specific exposure estimates were generated for TCE, PER and potentially confounding occupational exposures with a job-exposure matrix. A conditional logistic regression was conducted for exposure groups as well as for continuous cumulative exposure.HRs for liver cancer, NHL and MM but not kidney cancer were slightly elevated in groups with high exposure to PER (compared to occupationally unexposed subjects). HRs for liver cancer and NHL also increased with increasing continuous exposure to PER. We did not observe evidence for an association between exposure to TCE and NHL, MM or liver and kidney cancer.Although this study was subject to limitations related to the low prevalence of exposure to PER and TCE in the Nordic population and a limited exposure assessment strategy, we observed some evidence indicative of an excess risk of cancer of the liver and NHL in subjects exposed to PER.
机译：三氯乙烯（TCE）和全氯乙烯（PER）是两种氯化溶剂，被广泛用作金属零件的除油剂以及干洗和其他应用。 2012年，国际癌症研究机构将TCE归类为对人类致癌，而PER归类为对人类致癌。我们研究了北欧职业癌队列中TCE和PER与非霍奇金淋巴瘤（NHL），多发性骨髓瘤（MM）以及肾和肝癌的暴露-反应关系。该队列是通过将普查中的职业信息联系起来而建立的使用所有北欧国家/地区使用的个人识别码访问国家癌症注册数据。针对TCE，PER和可能与工作暴露矩阵混淆的职业暴露，生成了国家，时间段和针对特定工作的暴露估计。对暴露组以及持续累积暴露进行了条件logistic回归分析。在PER暴露较高的组中，肝癌，NHL和MM而非肾癌的HRs略有升高（与职业未暴露对象相比）。随着持续暴露于PER的增加，肝癌和NHL的HR也增加。我们没有观察到TCE与NHL，MM或肝癌和肾癌之间存在关联的证据，尽管这项研究受到与北欧人群PER和TCE的低患病率以及有限的暴露评估策略有关的限制，我们观察到一些证据表明暴露于PER的受试者存在肝癌和NHL的过度风险。

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