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首页> 外文期刊>Occupational and environmental medicine >Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane
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Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane

机译：暴露于1,2-二氯丙烷和/或二氯甲烷的胶版彩色证明印刷工人中的胆管癌

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Objectives The present study was conducted to investigate the relationship between occupational chemical exposure and incidence of cholangiocarcinoma among workers in the offset colour proof-printing section of a small printing company in Osaka, Japan. Methods We identified 51 men who had worked in the proof-printing room, and 11 men who had worked in the front room for at least 1 year between 1991 and 2006. We interviewed them about the chemicals they used, and estimated their levels of exposure to chemicals. We also investigated the medical records of 11 cholangiocarcinoma patients, and calculated the standardised mortality ratio (SMR) from 1991 to 2011. Results Workers used 1,2-dichloropropane (1,2-DCP) from approximately 1985 to 2006, and dichloromethane (DCM) from approximately 1985 to 1997/1998. Exposure concentrations were estimated to be 100-670 ppm for 1,2-DCP and 80-540 ppm for DCM among the proof-printing workers. All 11 patients were pathologically diagnosed with cholangiocarcinoma. Ages at diagnosis were 25-45 years, and ages at death were 27-46 years among the six deceased individuals. The primary cancer site was the intrahepatic bile duct for five patients, and the extrahepatic bile ducts for six. All patients were exposed to 1,2-DCP for 7-17 years and diagnosed with cholangiocarcinoma 7-20 years after their first exposure. Ten patients were also exposed to DCM for 1-13 years. The SMR for cholangiocarcinoma was 2900 (expected deaths: 0.00204, 95% CI 1100 to 6400) for all workers combined. Conclusions These findings suggest that 1,2-DCP and/or DCM may cause cholangiocarcinoma in humans.
机译：目的本研究旨在调查日本大阪一家小型印刷公司的胶版彩色打样印刷部门工人的职业化学暴露与胆管癌发生率之间的关系。方法在1991年至2006年期间，我们确定了51名在校样室工作的男性和11名在前室工作了至少1年的男性。我们就他们使用的化学品进行了访谈，并估计了其暴露水平化学药品。我们还调查了11名胆管癌患者的病历，并计算了1991年至2011年的标准化死亡率（SMR）。结果大约1985年至2006年，工人使用1,2-二氯丙烷（1,2-DCP），而二氯甲烷（DCM） ）大约从1985年到1997/1998年。校样工作人员的1,2-DCP暴露浓度估计为100-670 ppm，DCM的暴露浓度估计为80-540 ppm。所有11例患者均经病理诊断为胆管癌。在六名死者中，诊断年龄为25-45岁，死亡年龄为27-46岁。原发癌部位为肝内胆管5例，肝外胆管6例。所有患者首次接受1,2-DCP暴露7-17年，并在首次暴露7-20年后被诊断患有胆管癌。十名患者也暴露于DCM 1-13年。所有工人的合并胆管癌的SMR为2900（预期死亡：0.00204，95％CI 1100至6400）。结论这些发现表明1,2-DCP和/或DCM可能引起人类胆管癌。

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