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首页> 外文期刊>Occupational and environmental medicine >Occupational exposure to cobalt is not associated with incipient signs of dilated cardiomyopathy in a Belgian refinery.
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Occupational exposure to cobalt is not associated with incipient signs of dilated cardiomyopathy in a Belgian refinery.

机译：在比利时的炼油厂中，职业性接触钴与扩张型心肌病的初期迹象无关。

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摘要

Excessive absorption of cobalt has been associated with cases of dilated cardiomyopathy in the past, but it is unclear whether occupationally exposed populations are at risk.To assess the possible relationship between occupational exposure to cobalt and incipient signs of dilated cardiomyopathy.A cross-sectional survey was conducted in a cobalt production facility in Belgium constituting one of the largest occupational populations worldwide (n=256 male workers). Exposure to cobalt was assessed by measuring urinary cobalt concentration (μg/gcreat), reflecting recent exposure, and by computing an integrated exposure index (μg/gcreat×years), reflecting long-term exposure. The effect on the myocardium was investigated by echocardiography and electrocardiography, and dose-effect relations with cobalt exposure were traced by multiple regression analysis.No dose-effect relationship between exposure to cobalt and parameters reflecting dilated cardiomyopathy was found in a population of workers characterised by a median recent cobalturia of 4 μg/gcreat and a median long-term cobalturia of 100 μg/gcreat×years. A reduction in the dimensions of the left ventricular internal cavity was associated with recent exposure to cobalt.Occupational exposure to cobalt does not appear associated with incipient signs of dilated cardiomyopathy within the gradient of exposure recorded in this population.
机译：过去，钴的过度吸收与扩张型心肌病有关，但目前尚不清楚职业暴露人群是否处于危险之中，以评估职业暴露于钴与扩张型心肌病初期征兆之间的可能关系。是在比利时的钴生产厂中进行的，该厂是全球最大的职业人口之一（n = 256名男性工人）。通过测量反映近期暴露的尿中钴浓度（微克/肝脏）和计算反映长期暴露的综合暴露指数（微克/肝脏×年）来评估钴的暴露。通过超声心动图和心电图检查对心肌的影响，并通过多元回归分析追踪与钴暴露的剂量-效应关系，在特征为特征的工人人群中未发现钴暴露与反映扩张型心肌病的参数之间的剂量效应关系。最近的中性粒细胞增多症中位数为4μg/ g，长期长期中性粒细胞增多症中位数为100μg/ g×年。左心室腔的缩小与近期接触钴有关。在该人群记录的接触梯度内，职业性接触钴与扩张型心肌病的初期体征并不相关。

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