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首页> 外文期刊>Occupational and environmental medicine >Mortality and cancer incidence in a pooled cohort of US fire fighters from San Francisco, Chicago and Philadelphia (1950-2009)
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Mortality and cancer incidence in a pooled cohort of US fire fighters from San Francisco, Chicago and Philadelphia (1950-2009)

机译：来自旧金山，芝加哥和费城的美国消防员的汇集队列中的死亡率和癌症发生率（1950-2009年）

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Objectives: To examine mortality patterns and cancer incidence in a pooled cohort of 29 993 US career firefighters employed since 1950 and followed through 2009. Methods: Mortality and cancer incidence were evaluated by life table methods with the US population referent. Standardised mortality (SMR) and incidence (SIR) ratios were determined for 92 causes of death and 41 cancer incidence groupings. Analyses focused on 15 outcomes of a priori interest. Sensitivity analyses were conducted to examine the potential for significant bias. Results: Person-years at risk totalled 858 938 and 403 152 for mortality and incidence analyses, respectively. All-cause mortality was at expectation (SMR=0.99, 95% CI 0.97 to 1.01, n=12 028). There was excess cancer mortality (SMR=1.14, 95% CI 1.10 to 1.18, n=3285) and incidence (SIR=1.09, 95% CI 1.06 to 1.12, n=4461) comprised mainly of digestive (SMR=1.26, 95% CI 1.18 to 1.34, n=928; SIR=1.17, 95% CI 1.10 to 1.25, n=930) and respiratory (SMR=1.10, 95% CI 1.04 to 1.17, n=1096; SIR=1.16, 95% CI 1.08 to 1.24, n=813) cancers. Consistent with previous reports, modest elevations were observed in several solid cancers; however, evidence of excess lymphatic or haematopoietic cancers was lacking. This study is the first to report excess malignant mesothelioma (SMR=2.00, 95% CI 1.03 to 3.49, n=12; SIR=2.29, 95% CI 1.60 to 3.19, n=35) among US firefighters. Results appeared robust under differing assumptions and analytic techniques. Conclusions: Our results provide evidence of a relation between firefighting and cancer. The new finding of excess malignant mesothelioma is noteworthy, given that asbestos exposure is a known hazard of firefighting.
机译：目的：研究1950年以来直至2009年的29993名美国职业消防员的队列，研究其死亡率模式和癌症发病率。方法：采用生命表方法，结合美国人群作为参考，评估死亡率和癌症发病率。确定了92个死亡原因和41个癌症发病率分组的标准死亡率（SMR）和发病率（SIR）比率。分析重点放在先验兴趣的15个结果上。进行了敏感性分析，以检查潜在的重大偏见。结果：高危人群的死亡率和发生率分析分别为858 938和403 152。全因死亡率符合预期（SMR = 0.99，95％CI 0.97至1.01，n = 12028）。主要由消化道疾病引起的癌症死亡率过高（SMR = 1.14，95％CI 1.10至1.18，n = 3285）和发生率（SIR = 1.09，95％CI 1.06至1.12，n = 4461） CI 1.18至1.34，n = 928; SIR = 1.17，95％CI 1.10至1.25，n = 930）和呼吸道（SMR = 1.10，95％CI 1.04至1.17，n = 1096; SIR = 1.16，95％CI 1.08至1.24，n = 813）。与以前的报道一致，在几种实体癌中观察到适度的升高;然而，缺乏过多的淋巴或造血癌症的证据。这项研究是第一个报告美国消防员中过量的恶性间皮瘤（SMR = 2.00，95％CI 1.03至3.49，n = 12; SIR = 2.29，95％CI 1.60至3.19，n = 35）。在不同的假设和分析技术下，结果似乎很可靠。结论：我们的结果提供了消防与癌症之间关系的证据。鉴于石棉暴露是已知的消防危险，因此新发现的过量恶性间皮瘤值得关注。

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