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首页> 外文期刊>Occupational and environmental medicine >Cohort mortality and cancer incidence survey of recent entrants (1982-91) to the United Kingdom rubber industry: preliminary findings.
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Cohort mortality and cancer incidence survey of recent entrants (1982-91) to the United Kingdom rubber industry: preliminary findings.

机译：最近进入英国橡胶行业的新兵（1982-91年）的队列死亡率和癌症发病率调查：初步发现。

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OBJECTIVES: To monitor the occurrence of stomach and lung cancer in a newly defined cohort of United Kingdom rubber workers and to report findings for other cancers in an early period of follow up. METHODS: A prospective cohort of 9031 male and female workers from 42 United Kingdom rubber factories has been enumerated. All employees had a minimum of 12 months employment and were first employed at one of the participating factories in the period 1982-91. Mortality data were available for the period 1983-98 and cancer registration data for the period 1983-94. The mortality and cancer incidence experienced by the cohort were compared with expected values based on national rates defined by period, age, and sex. RESULTS: Mortality from lung cancer was close to expectation (men: observed (obs) 11, expected (exp) 12.70, standardised mortality ratio (SMR) 87, 95% confidence interval (95% CI) 43 to 155; women: obs 0, exp 1.34, SMR 0, 95% CI 0 to 275). Mortality from stomach cancer was unexceptional (men: obs 1, exp 2.69, SMR 37, 95% CI 1 to 207; women: obs 0, exp 0.24, SMR 0, 95% CI 0 to 1537). Many statistical comparisons were made both for mortality data and for cancer registration data; only one difference between observed and expected numbers was significant (mortality from cancer of the testis: obs 3 exp 0.51, SMR 589, 95% CI 122 to 1722). Corresponding findings for incident cancers of the testis were unexceptional (obs 5, exp 5.13, standardised registration ratio (SRR) 97, 95% CI 32 to 227). CONCLUSION: The findings should be treated with caution as they relate to an early period of follow up. Nevertheless, they hold out the prospect that the increased SMRs for stomach and lung cancers reported for historical cohorts of United Kingdom rubber workers may not be apparent in more recent cohorts.
机译：目的：监测新定义的英国橡胶工人队列中胃癌和肺癌的发生，并在随访的早期阶段报告其他癌症的发现。方法：列举了来自英国42家橡胶厂的9031名男女工人的预期队列。所有员工至少有12个月的工作，并于1982-91年期间首先在其中一个参与工厂工作。可获得1983-98年期间的死亡率数据和1983-94年期间的癌症登记数据。将队列中所经历的死亡率和癌症发病率与基于年龄，年龄和性别定义的全国比率的预期值进行比较。结果：肺癌的死亡率接近预期（男性：观察（肥胖）11，预期（经验）12.70，标准化死亡率（SMR）87、95％置信区间（95％CI）43至155;女性：肥胖0 （exp 1.34，SMR 0、95％CI 0至275）。胃癌的死亡率异常高（男性：obs 1，exp 2.69，SMR 37，95％CI 1至207;女性：obs 0，exp 0.24，SMR 0，95％CI 0-1537）。对死亡率数据和癌症登记数据进行了许多统计比较;观察到的数字与预期的数字之间只有一个显着差异（睾丸癌的死亡率：obs 3 exp 0.51，SMR 589，95％CI 122至1722）。睾丸癌的相应发现无异常（obs 5，exp 5.13，标准化注册比率（SRR）97，95％CI 32至227）。结论：与早期随访有关的发现应谨慎对待。然而，他们认为，英国橡胶工人的历史性队列报道的胃癌和肺癌SMR升高的趋势在最近的队列中可能并不明显。

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