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首页> 外文期刊>Occupational and environmental medicine >Lung cancer in Yorkshire chrome platers, 1972-97.
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Lung cancer in Yorkshire chrome platers, 1972-97.

机译：约克郡镀铬电镀厂的肺癌，1972-97年。

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OBJECTIVES: To investigate mortality from lung cancer in chrome platers, a group exposed to chromic acid. METHODS: The mortality of a cohort of 1087 chrome platers (920 men, 167 women) from 54 plants situated in the West Riding of Yorkshire, United Kingdom, was investigated for the period 1972-97. All subjects were employed as chrome platers for >/=3 months and all were alive on 31 May 1972. Mortality data were also available for a cohort of 1163 comparison workers with no known occupational exposure to chrome compounds (989 men, 174 women). Information on duration of chrome work and smoking habits collected for a cross sectional survey carried out in 1969-72 were available for 916 (84.3%) of the chrome platers; smoking habits were available for 1004 (86.3%) comparison workers. Two analytical approaches were used, indirect standardisation and Poisson regression. RESULTS: Based on serial mortality rates for the general population of England and Wales, significantly increased mortality from lung cancer was observed (obs) in male chrome platers (obs 60, expected (exp) 32.5, standardised mortality ratio (SMR) 185, p<0. 001) but not in male comparison workers (obs 47, exp 36.9, SMR 127). Positive trends were not shown for duration of employment exposed to chrome, although data on working after 1972 were not available. CONCLUSIONS: Confident interpretation is not possible but occupational exposures to hexavalent chromium may well have been involved in the increased mortality from lung cancer found in this cohort of chrome platers.
机译：目的：研究铬铬酸盐（一组暴露于铬酸中）引起的肺癌死亡率。方法：调查了一组来自英国约克郡西郊地区54家工厂的1087名镀铬工人（920名男性，167名女性）在1972-97年期间的死亡率。所有受试者均接受铬电镀，时间≥/ = 3个月，并且均于1972年5月31日活着。还获得了1163名没有已知职业接触铬化合物的比较工人的死亡率数据（989名男性，174名女性）。在1969-72年进行的一次横断面调查中，收集了关于铬工作时间和吸烟习惯的信息，适用于916名（84.3％）镀铬工人。 1004名比较工人有吸烟习惯（86.3％）。使用了两种分析方法：间接标准化和泊松回归。结果：基于英格兰和威尔士普通人群的系列死亡率，男性铬电镀工人的肺癌死亡率（obs）显着增加（obs 60，预期（exp）32.5，标准死亡率（SMR）185，p <0。001），但男性比较工人则不然（obs 47，exp 36.9，SMR 127）。尽管没有1972年以后的工作数据，但铬暴露的就业时间并未显示出积极的趋势。结论：不可能有把握的解释，但是在六价铬的职业人群中，六价铬的职业暴露很可能与肺癌死亡率的增加有关。

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