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首页> 外文期刊>Occupational and environmental medicine >Role of human neurobehavioural tests in regulatory activity on chemicals.
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Role of human neurobehavioural tests in regulatory activity on chemicals.

机译：人类神经行为测试在化学品监管活动中的作用。

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Psychological performance tests have been used since the mid-1960s in occupational and environmental health toxicology. The interpretation of significantly different test scores in neurobehavioural studies is not straightforward in the regulation of chemicals. This paper sets out some issues which emerged from discussions at an international workshop, organised by the United Kingdom Health and Safety Executive (HSE), to discuss differences in interpretation of human neurobehavioural test data in regulatory risk assessments. The difficulties encountered by regulators confronted with neurobehavioural studies seem to be twofold; some studies lack scientific rigor; other studies, although scientifically sound, are problematic because it is not clear what interpretation to place on the results. Issues relating to each of these points are discussed. Next, scenarios within which to consider the outcomes of neurobehavioural studies are presented. Finally, conclusions and recommendations for further work are put forward.
机译：自1960年代中期以来，就一直在职业和环境健康毒理学中使用心理性能测试。在神经行为研究中，对明显不同的测试分数的解释在化学​​物质的调节中并不简单。本文提出了一些问题，这些问题是由英国健康与安全执行官（HSE）组织的一次国际研讨会上的讨论中出现的，以讨论在监管风险评估中人类神经行为测试数据解释的差异。监管者在进行神经行为学研究时遇到的困难似乎是双重的。一些研究缺乏科学严谨性;其他研究尽管具有科学依据，但仍存在问题，因为尚不清楚对结果应采用何种解释。讨论了与这些要点有关的问题。接下来，介绍了考虑神经行为研究结果的方案。最后，提出了进一步工作的结论和建议。

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