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首页> 外文期刊>Occupational and environmental medicine >Update of the morbidity experience of employees potentially exposed to chlorpyrifos.
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Update of the morbidity experience of employees potentially exposed to chlorpyrifos.

机译：更新可能接触毒死rif的员工的发病率经验。

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OBJECTIVES: Chlorpyrifos, an organophosphate ingredient of several important insecticides, has been manufactured at The Dow Chemical Company for 25 years. A previous morbidity study among employees of The Dow Chemical Company found no increased prevalence of illness or symptoms among employees potentially exposed to chlorpyrifos from 1977 to 1985 compared with matched controls. The purpose of the current study was to update the original study to 1994, thereby increasing the statistical power. METHODS: In the present study, 496 potentially exposed subjects were identified and matched for age, race, sex, pay, and year of hire to 911 control subjects. Morbidity data were abstracted from company medical records. RESULTS: The prevalence of peripheral neuropathy was not significantly increased among this group of employees potentially exposed to chlorpyrifos. Significantly increased prevalence odds ratios were identified for five diagnostic categories: diseases of the ear and mastoid process; acute respiratory infections; other diseases of the respiratory system; general symptoms, signs, and ill defined conditions; and symptoms, signs, and ill defined conditions involving the digestive system. There was a strong association of diagnosis with duration of observation period, indicating that the exposed workers were more likely than unexposed workers to have a diagnosis abstracted from the company medical records due to their longer mean period of follow up. Analyses by exposure classification and mean plasma cholinesterase activity did not show a dose response. CONCLUSIONS: These data do not support a cause and effect relation of the diagnoses mentioned and exposure to chlorpyrifos.
机译：目的：毒死rif是几种重要杀虫剂的有机磷酸盐成分，已经在陶氏化学公司生产了25年。陶氏化学公司（Dow Chemical Company）员工之前的发病率研究发现，与对照组相比，1977年至1985年期间可能暴露于毒死rif的员工中疾病或症状的患病率没有增加。本研究的目的是将原始研究更新到1994年，从而提高统计能力。方法：在本研究中，确定了496名潜在暴露的受试者，并将其与911名对照受试者的年龄，种族，性别，薪水和雇用年限相匹配。从公司病历中提取发病率数据。结果：在可能暴露于毒死rif的这一组雇员中，周围神经病变的患病率没有显着增加。五个诊断类别的患病几率显着提高：耳朵和乳突过程疾病;急性呼吸道感染;呼吸系统的其他疾病;一般症状，体征和病情不明确;以及与消化系统有关的症状，体征和病情不佳。诊断与观察期的持续时间有很强的关联性，这表明由于暴露时间较长的平均随访时间，暴露工人比未暴露工人更有可能从公司病历中提取诊断信息。通过暴露分类和平均血浆胆碱酯酶活性的分析未显示剂量反应。结论：这些数据不支持上述诊断与毒死rif接触的因果关系。

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