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首页> 外文期刊>Occupational and environmental medicine >Association between exposure to crystalline silica and risk of sarcoidosis.
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Association between exposure to crystalline silica and risk of sarcoidosis.

机译：接触结晶二氧化硅与结节病风险之间的关联。

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OBJECTIVES: The possibility of an association between exposure to silica and autoimmune diseases has recently come under discussion. In the following case-referent study, a cohort exposed to diatomaceous earth and cristobalite provided an opportunity to evaluate such an exposure with reference to sarcoidosis. METHODS: The inhabitants of a district served by a single healthcare centre and a hospital formed the study base. A diatomaceous earth plant is located in this community and the medical institutions are responsible for primary and secondary health care of the population. Cases of sarcoidosis were identified from the hospital records according to certain clinical, radiological, and histological criteria. Referents were selected randomly from the population of the district. Information on exposure to crystalline silica, cristobalite, was obtained by record linkage of the cases and referents with a file which included all present and past workers at the diatomaceous earth plant and those who had worked at loading vessels with the product from the plant. RESULTS: Eight cases of sarcoidosis were found, six of which were in the exposed group. Of the 70 referents, 13 were exposed. The odds ratio (95% confidence interval) was 13.2 (2.0 to 140.9). CONCLUSION: The odds ratios were high and there were some indications of a dose-response relation which will hopefully encourage further studies. To our knowledge this is the first study to indicate a relation between sarcoidosis and exposure to the crystalline silica, cristobalite.
机译：目的：接触二氧化硅和自身免疫性疾病之间的联系的可能性最近正在讨论中。在以下病例参考研究中，暴露于硅藻土和方石英的人群提供了一个评估结节病的机会。方法：由一个医疗中心和一家医院服务的地区的居民组成了研究基地。硅藻土工厂位于该社区，医疗机构负责人口的初级和二级保健。根据某些临床，放射学和组织学标准，从医院记录中确定结节病病例。从该地区的人口中随机选择对象。通过案例和参考对象之间的记录链接获得了与晶状硅石方石英接触的信息，该文件包括了硅藻土工厂的所有现任和过去的工人以及曾用该工厂的产品装载船只的工人。结果：发现结节病8例，其中暴露组6例。在70名对象中，有13名暴露在外。优势比（95％置信区间）为13.2（2.0至140.9）。结论：比值比很高，并且有迹象表明存在剂量反应关系，这有望鼓励进一步的研究。据我们所知，这是第一个表明结节病和接触结晶二氧化硅，方石英之间关系的研究。

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