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首页> 外文期刊>Occupational and environmental medicine >Tyler asbestos workers: mortality experience in a cohort exposed to amosite.
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Tyler asbestos workers: mortality experience in a cohort exposed to amosite.

机译：泰勒（Tyler）石棉工人：在一个暴露于铁石棉的队列中的死亡率经验。

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OBJECTIVES: To examine the causes of death among 1130 former workers of a plant in Tyler, Texas dedicated to the manufacture of asbestos pipe insulation materials. This cohort is important and unusual because it used amosite as the only asbestiform mineral in the production process. High level exposure of such a specific type was documented through industrial hygiene surveys in the plant. METHODS: Deaths were ascertained through various sources including data tapes from the Texas Department of Health and the national death index files. As many death certificates as possible were secured (304/315) and cause of death assigned. After select exclusions, 222 death certificates were used in the analysis. Causes of death were compared with age, race, and sex specific mortalities for the United States population with a commercial software package (OCMAP Version 2.0). RESULTS: There was an excess of deaths from respiratory cancer including the bronchus, trachea, and lung (standardised mortality ratio (SMR) 277 with 95% confidence interval (95% CI) 193 to 385). Four pleural mesotheliomas and two peritoneal mesotheliomas were identified. The analysis also showed an increasing risk of respiratory malignancy with increased duration of exposure including a significant excess of total deaths from respiratory cancer with less than six months of work at the plant (SMR 268 with 95% CI 172 to 399). CONCLUSIONS: The importance of the cohort lies with the pure amosite exposure which took place in the plant and the extended period of latency which has followed. The death certificate analysis indicates the pathogenicity of amosite, the predominant commercial amphibole used in the United States. These data confirm a link between amosite asbestos and respiratory malignancy as well as mesothelioma.
机译：目的：研究德克萨斯州泰勒一家工厂的1130名前工人的死亡原因，该工厂专门生产石棉管道绝缘材料。该队列非常重要且不寻常，因为它在生产过程中将铁石棉用作唯一的石棉矿物。通过工厂的工业卫生调查记录了这种特定类型的高暴露水平。方法：死亡通过各种来源确定，包括得克萨斯州卫生部的数据磁带和国家死亡指数文件。确保了尽可能多的死亡证明（304/315）并指定了死因。在选择排除之后，在分析中使用了222张死亡证书。使用商业软件包（OCMAP 2.0版），将死亡原因与美国人口的年龄，种族和特定性别的死亡率进行了比较。结果：包括支气管，气管和肺在内的呼吸道癌症死亡人数过多（标准死亡率（SMR）277，置信区间为95％（95％CI）193至385）。确定了四个胸膜间皮瘤和两个腹膜间皮瘤。分析还显示，随着暴露时间的延长，呼吸道恶性肿瘤的风险增加，包括在工厂工作少于六个月（SMR 268，CI为172到399，95％CI）导致的呼吸道癌症总死亡人数明显过量。结论：该队列的重要性在于植物中发生的纯铁矿接触和随之而来的潜伏期延长。死亡证明书分析表明，铁石棉的致病性，铁石棉是美国使用的主要商业闪石。这些数据证实了铁质石棉与呼吸道恶性肿瘤以及间皮瘤之间的联系。

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