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Risk of soft tissue sarcomas and residence in the neighbourhood of an incinerator of industrial wastes.

机译:软组织肉瘤和在工业废物焚化炉附近居住的风险。

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摘要

AIMS: To investigate the association between occurrence of soft tissue sarcomas (STS) in Mantua and residence near an incinerator of industrial wastes. METHODS: Cases were subjects with histologically confirmed primary malignant STS diagnosed 1989-98 in the population resident in Mantua and in the three neighbouring municipalities. Controls were randomly extracted from population registries, matched for age and sex. Residential history was reconstructed for all study subjects since 1960. Main residence was geographically positioned according to GPS standards. RESULTS: The study included 37 STS cases (17 men and 20 women) and 171 controls. The incidence of STS in the area of study was estimated as 8.8 per 100 000 in men and 5.6 per 100 000 in women. The odds ratio associated with residence within 2 km, standardised by age and sex, was 31.4 (95% CI 5.6 to 176.1), based on five exposed cases. At greater distances, risk rapidly decreased, showing a fluctuation around the null value of 1. CONCLUSION: The study shows a significant increase in risk of STS associated with residence within 2 km of an industrial waste incinerator; an aetiological role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can be hypothesised.
机译:目的:研究曼图亚的软组织肉瘤(STS)的发生与工业废物焚化炉附近居住之间的关系。方法:病例是在曼图亚和三个邻近城市的居民中,经组织学确认为1989-98年诊断为原发性恶性STS的受试者。从人口登记处随机抽取对照,按年龄和性别进行匹配。自1960年以来,所有研究对象的住所历史都得到了重建。主要住所的地理位置根据GPS标准确定。结果:该研究包括37例STS病例(17例男性和20例女性)和171例对照。在研究领域中,STS的发病率估计为:男性每十万人中8.8,女性每十万人中5.6。根据5例暴露病例,与2公里以内居住相关的优势比按年龄和性别分类为31.4(95%CI 5.6至176.1)。在更远的距离,风险迅速降低,在零值附近波动。结论:研究表明,与工业垃圾焚烧炉2 km内居住相关的STS风险显着增加。可以假设2,3,7,8-四氯二苯并-p-二恶英(TCDD)的病因作用。

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