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首页> 外文期刊>Occupational and environmental medicine >Lung cancer risk in workers exposed to poly(vinyl chloride) dust: a nested case-referent study.
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Lung cancer risk in workers exposed to poly(vinyl chloride) dust: a nested case-referent study.

机译：接触聚氯乙烯粉尘的工人患肺癌的风险：一项嵌套病例参考研究。

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BACKGROUND: There have been few investigations of an association between poly(vinyl chloride) (PVC) dust exposure and an increase in lung cancer incidence, and their conclusions have been inconsistent. AIMS: To determine whether PVC and/or vinyl chloride monomer (VCM) is the associated risk factor(s), by means of a nested case-referent study, in order to estimate lung cancer risk, avoiding selection, information, or confounding biases. METHODS: Thirty eight cases of histologically verified lung cancer and 224 control subjects without a history of cancer were selected from an Italian cohort of 1658 vinyl chloride workers. Information sources included clinical records (diagnosis, smoking habits) and plant records (occupational history). The risk of lung cancer was estimated by odds ratios (OR) with 95% confidence intervals (CI), calculated using logistic regression models. RESULTS: In PVC baggers exposed to high levels of respirable PVC particles in the workplace, the lung cancer OR increases by 20% for each extra year of work (OR = 1.2003; 95% CI 1.0772 to 1.3469; p = 0.0010), when the influence of age and smoking habits is controlled. No relation was found between lung cancer and cumulative VCM exposure. CONCLUSION: This nested case-control study showed, in the VCM/PVC industry, an increased risk of lung cancer associated with exposure to PVC dust; previous cohort studies failed to recognise such excess, probably because they used VCM exposure as the risk indicator.
机译：背景：关于聚氯乙烯（PVC）粉尘暴露与肺癌发生率增加之间的关联的研究很少，其结论并不一致。目的：通过嵌套病例参考研究确定PVC和/或氯乙烯单体（VCM）是否是相关的危险因素，以评估肺癌风险，避免选择，信息或混淆性偏见。方法：从1658名氯乙烯工人的意大利队列中选择了38例经组织学证实为肺癌的病例和224例无癌史的对照受试者。信息来源包括临床记录（诊断，吸烟习惯）和植物记录（职业病史）。肺癌的风险通过使用逻辑回归模型计算的比值比（OR）和95％置信区间（CI）进行估算。结果：在工作场所暴露于大量可吸入PVC颗粒的PVC装袋机中，每增加一年的工作时间，肺癌OR升高20％（OR = 1.2003; 95％CI 1.0772至1.3469; p = 0.0010）年龄和吸烟习惯的影响得到控制。肺癌与VCM累积暴露之间没有关系。结论：这项嵌套的病例对照研究表明，在VCM / PVC行业中，暴露于PVC粉尘会增加患肺癌的风险。先前的队列研究未能识别出这种过量，可能是因为他们使用VCM暴露作为风险指标。

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